Mannan-Binding Lectin Enhances Susceptibility to Visceral Leishmaniasis
AUTOR(ES)
de Miranda Santos, Isabel K. F.
FONTE
American Society for Microbiology
RESUMO
Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=98624Documentos Relacionados
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