Effect of Capsulation of Opportunistic Pathogenic Bacteria on Binding of the Pattern Recognition Molecules Mannan-Binding Lectin, L-Ficolin, and H-Ficolin
AUTOR(ES)
Krarup, Anders
FONTE
American Society for Microbiology
RESUMO
Mannan-binding lectin (MBL), L-ficolin, and H-ficolin are pattern recognition molecules of the innate immune system. We investigated their ability to bind to different serotypes and noncapsulated variants of two gram-positive bacterial species, Streptococcus pneumoniae and Staphylococcus aureus. MBL did not bind to capsulated S. aureus or capsulated S. pneumoniae but did bind to a noncapsulated S. aureus variant (Wood). L-ficolin bound to some capsulated S. aureus serotypes (serotypes 1, 8, 9, 11, and 12) and capsulated S. pneumoniae serotypes (11A, 11D, and 11F) but not to noncapsulated strains. H-ficolin did not bind to any of the S. pneumoniae and S. aureus serotypes included in this study but did bind to one strain of Aerococcus viridans. The concentrations of the three proteins in 97 plasma samples were estimated. The median concentrations were 0.8 μg per ml for MBL, 3.3 μg per ml for L-ficolin, and 18.4 μg per ml for H-ficolin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=547010Documentos Relacionados
- Mannan-Binding Lectin Enhances Susceptibility to Visceral Leishmaniasis
- Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment
- Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: Mannan-binding proteindependent cell-mediated cytotoxicity
- H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients
- Characterization of β-Glucan Recognition Site on C-Type Lectin, Dectin 1