Inhibition of humoral and cell-mediated immune responses in man by distinct suppressor cell systems.
AUTOR(ES)
Lobo, P I
RESUMO
Studies were designed to investigate whether the suppressor cell systems that regulate the humoral and cell-mediated immune responses belong to the same subsets of T cells or different subsets. Mitogen-activated suppressor cells were simultaneously assayed for their ability to inhibit (a) pokeweed mitogen-induced generation of plasma cells, (b) blastogenic response of lymphocytes to allogeneic cells, and (c) generation of killer cells in the cell-mediated lymphocytotoxicity assay. We found that suppressor cells that inhibited the generation of plasma cells were activated by concanavalin A (Con A) and were both radiation and prednisone sensitive. Suppressors that inhibited the blastogenic response in lymphocytes to allogenic cells were also activated by Con A but differed in that they were both radiation and prednisone resistant. In contrast, suppressors that inhibited the generation of the killer cells were activated with phytohemagglutinin and not Con A. These suppressors were prednisone and radiation resistant. These observations cannot be explained by differences at the pro-suppressor or suppressor activator levels as both T cell subsets are radiosensitive. Alternatively, heterogeneity of suppressor cell systems may explain these differences.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=372063Documentos Relacionados
- Suppression of cell-mediated and humoral immune responses by an interleukin-2-immunoglobulin fusion protein in mice.
- Suppressor cell regulation of cell-mediated immune responses in renal infection in vitro modulation of suppressor cell activity.
- NK cell–mediated killing of target cells triggers robust antigen-specific T cell–mediated and humoral responses
- Humoral and cell-mediated immune responses in humans before and after revaccination with vaccinia virus.
- Cell-mediated and humoral immune responses to herpes simplex virus and cytomegalovirus in renal transplant patients.