In Vitro Effects of Carbenicillin Combined with Gentamicin or Polymyxin B Against Pseudomonas aeruginosa1
AUTOR(ES)
Eickhoff, Theodore C.
RESUMO
Disodium carbenicillin and gentamicin sulfate have both shown promise in the treatment of infections caused by Pseudomonas aeruginosa. This study was designed to explore possible synergistic relationships among the new as well as the established antimicrobial agents used to treat such infections. With an agar dilution technique, minimum inhibitory concentrations of 27 strains of P. aeruginosa were determined in two-dimensional tests. Graphs of equal biological activity (isobolograms) demonstrated moderate synergistic effects of the carbenicillin-gentamicin combination over therapeutically feasible concentration ranges. In contrast, the combination of carbenicillin and polymyxin B showed only additive or slightly antagonistic effects. Tests of bacterial killing confirmed the presence of carbenicillin-gentamicin synergy in 3 of 6 strains of P. aeruginosa, but did not show true antagonism between carbenicillin and polymyxin B. Clinical trials of both drug combinations are advisable to determine whether therapeutic results can be improved, and whether the dosages of gentamicin or polymyxin B can thereby be reduced to lessen their toxic hazards.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=378006Documentos Relacionados
- Combined Action of Carbenicillin and Gentamicin on Pseudomonas aeruginosa In Vitro
- Susceptibility of Pseudomonas aeruginosa to Tobramycin or Gentamicin Alone and Combined with Carbenicillin
- Susceptibility of Pseudomonas aeruginosa to Tobramycin or Gentamicin Alone and Combined with Carbenicillin
- Susceptibility of 1,500 Isolates of Pseudomonas aeruginosa to Gentamicin, Carbenicillin, Colistin, and Polymyxin B
- Comparison of the In Vitro Activity of BL-P1654 with Gentamicin and Carbenicillin Against Pseudomonas aeruginosa