Impact of diet and glutathione s-transferase system genotype in the susceptibility to cancer / Impacto do perfil alimentar e genotipico do sistema glutationa S-transferase na susceptibilidade ao cancer

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Background: Glutathione-S-Transferase gene family has an important role in the biotransformation and detoxification of different xenobiotics and endogenous compounds. The high admixture of the Brazilian population may represent a unique model in which the types and frequency of genetic polymorphisms of GST enzymes are less influenced by ethnicity. Objective: In order to evaluate the influence of GST profile in different age and gender groups regarding the risk to develop câncer, we studied GSTT1, GSTM1, GSTP1 in 1278 Brazilian individuals comparing 395 individuals with confirmed diagnosis of ovarian, prostate or thyroid câncer to 883 câncer-free control subjects. We used a polymerase chain reaction-based assay for genotyping. Results: GSTP1 polymorphism was related to câncer in males (p<0.001). Indeed, men that presented a polymorphic GSTP1 gene were 2.58 times more susceptible to develop malignancies (OR=2.58; 95% CI: 1.63-4.06). Multivariate analysis of GSTT1 and GSTM1 in the stratified groups demonstrated that GSTT1 and GSTM1 combined null inheritance in men over 45 years old increased by 88% their chance to develop a malignancy (p=0.035; OR=1.88; 95% CI:1.05-3.39). Conclusions: Our data support previous case-control studies suggesting that GST genotypes and nutrition modify individual risk of environmentally-induced cancers

ASSUNTO(S)

genes tireoide ovarian cancer ovarios neoplasms prostate nutrição prostata nutrition thyroid

ACESSO AO ARTIGO

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