Evaluation of the mechanics of the respiratory system using PV curves in patients with idiopathic pulmonary fibrosis / Avaliação da mecânica do sistema respiratório através da obtenção de curva PV em pacientes com pneumonia intersticial idiopática

AUTOR(ES)

Juliana Carvalho Ferreira

DATA DE PUBLICAÇÃO

2008

RESUMO

The objective of this study was to evaluate small airways compromise in Idiopathic Pulmonary Fibrosis (IPF) using pressure-volume (PV) curves of the respiratory system. We collected PV curves from twelve patients before lung biopsy, which confirmed IPF in seven patients and Hipersensitivity Pneumonia in five. All curves were fitted with a sigmoid model, V = a + b / (1 + e -(P-c/d)), and an exponential model, V = A - B . e -k.P (applied only to the superior part of the curve). The exponential model, despite having a good fit to the superior part of the curve, did not represent the initial part, and yielded parameters with no physiological meaning. The sigmoid model had a good fit to the entire curve and yielded parameters with physiological meaning, suggesting the presence of small airways collapse in IPF.

ASSUNTO(S)

interstitial lung diseases fibrose pulmonar/fisiopatologia sistema respiratório respiratory system doenças pulmonares intersticiais respiratory mechanics mecânica respiratória pulmonary fibrosis/physiopathology

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