Evaluation of intermittent administration of parathyroid hormone in the repair process of rat calvaria defects / Avaliação da administração intermitente de hormonio paratireoideo no reparo de defeitos na calvaria de ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

The study aimed to investigate the effects ofintermittent parathyroid hormone PTH(1-34) treatment on bone regeneration of critically sized rat calvarial bone defects. A fullthickness bone defect (diameter 4 mm) was trephined in the central part of the parietal bones in ten-week old male Wistar rats. The animaIs were then divided into 2 groups of 16. The PTH group was subcutaneously administered with 40 microg PTH(1-34) /kg 3 times a week and to the control group it was given the vehicle. The rats were sacrificed at 28 days post surgery, the parietal bones were extracted, X- rayed and samples were prepared to obtain decalcified histological sections. The results were evaluated radiodensitometrically and histomorphometrically. The histomorphometric analysis for residual bone defect, using an image analyzer software, showed the mean values of 1.5mm for PTH group and 1.98mm for control group; indicating statistical significant differences among groups p<0.05 (test t). The photodensitometer analysis demonstrated a lower bone density in the group that did not receive PTH treatment (p<0.01). The experiment demonstrated that intermittent PTH (1-34) treatment could acelerate healing of rat calvarial defects

ASSUNTO(S)

cranio parathyroid hormone bone regeneration hormonio paratireoideo skull ossos - regeneração

ACESSO AO ARTIGO

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