Influence of hPTH (1-34) intermittent administration in rats lower incisor alveolar socket Sharpey fibers and in hepatocytes ultrastructure / Influencia da administração intermitente de hormonio paratireoideo humano fragmento (1-34) nas fibras de sharpey da face lingual do alveolo de incisivos inferiores e na ultraestrutura dos hepatocitos de ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

The aim of this study was to evaluate the effects of PTH intermittent treatment on periodontal Sharpey fibers and hepatocytes ultrastructural components of wistar rats. The animals were divided in groups and exposed to different occlusaI forces, normal occlusion, hyperfunction and hypofunction. PTH treated animais received 40 mu g/Kg of PTH, three times a week, during thirty days and the rats from control group received vehicle in following the same protocol. Sharpey fibers density was evaIuated through scanning electron microscopy in the lingual face of lower incisors. We observed that PlH treated animaIs presented increased density of Sharpey fibers and more mineralized fibers, in the three occ1usal conditions analyzed, when compared to the control. Transmission electronic microscopy morphometric anaIysis demonstrated that hepatocytes from PTH treated animals presented an increase of smooth endoplasmatic reticulum and a decrease on glycogen volumetric density. These results indicate that thirty days of PTH intermittent administration are responsible by an increase in aIveolar Sharpey fibers density and this evidence might be associated to an enhancement of periodontal ligament resistance and consequently to reduced eruptive rates previously observed. In hepatic tissue the increase in smooth endoplasmatic reticulum and the reduction in glycogen amount induced by PTH might be related to an enhancement of hepatic metabolism promoted by the hormone

ASSUNTO(S)

liver dentes - erupção figado tooth eruption

ACESSO AO ARTIGO

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