Estudo in vitro sobre a interação celular e vias endocíticas de papilomavírus humano (HPV) em leucócitos do sangue periférico. / In vitro study on the interaction of human papillomavirus in cell from peripheral blood leukocytes.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Human papillomavirus (HPV) is the primary etiologic agent of anogenital and cervical cancer, caused mainly by the high-risk HPV16 and HPV18 viruses. Recent studies revealed that besides the sexual transmission of HPV, there are other forms of contagion. However, the difficulty in obtaining quantities of viable wild-type or mutant of HPV constitutes a limiting factor in the studies of various aspects of the biology of human papillomavirus. This study investigated the possibility of HPV infect the cells of human peripheral blood leukocytes. We conclude that the VLPs L1L2 of HPV16 may use the iron endocytic pathway clathrin-mediated through the complex VLPs-Transferrin-Transferrin Receptor and remained so latent in leukocytes. This port of entry opportunist could explain the growing and alarming spread of this disease to human health, cause for concern in the global public health. This study showed for the first time the internalization of VLPs L1L2 of HPV16 in human peripheral blood leukocytes.

ASSUNTO(S)

saúde pública production of vlps biotechnology public health neoplasms transferrina- receptor de transferrina anogenital cancer papillomavirus (human) neoplasias biotecnologia leucócitos (separação) papillomavirus (humano) câncer anogenital transferrin-transferrin receptor leukocytes (separation) produção de vlps

ACESSO AO ARTIGO

Documentos Relacionados