Estudo comparativo com ressonância magnética cerebral em idosos com transtorno afetivo bipolar usuários ou não de litio / Comparative study with magnetic resonance imaging in elderly bipolar patients in use or non-use of lithium

AUTOR(ES)

Stevin Parreira Zung

DATA DE PUBLICAÇÃO

2007

RESUMO

Recent studies have demonstrated that lithium exerts relevant neuronal protective and regenerative effects both in vitro and in vivo. The aim of the study is to compare volumetric differences of gray matter regions associated with memory (hippocampus/parahipocampal gyrus, amygdala, posterior cingulate and precuneus) between 30 elderly bipolar patients using lithium, 27 elderly bipolar patients not using lithium and 22 healthy elderly controls. Volumetric differences were also investigated between elderly bipolar patients and healthy elderly controls. Volumetric differences were investigated with voxel-based morphometry based upon the Statistical Parametric Mapping technique. There were no statistical differences on socio-demographic characteristics between the groups, nor clinical characteristics and course of bipolar disorder between the group of patients using lithium and the group not using lithium. The volume of left parahippocampal gyrus (p = 0,01 corrected for multiple comparisons) and thalamus and caudate bilaterally (p = 0,034 corrected) were increased in the lithium group relative to the non lithium group. There was a positive association between left parahippocampal gyrus and dose of lithium and serum lithium level of those bipolar patients who were taking this medication. Posterior cingulate area was increased in bipolar patients not taking lithium when compared to those using this medication (p=0,005 corrected). Volumetric comparisons between bipolar patients and elderly controls showed increased volume in right superior and medium temporal gyrus in the bipolar group (p = 0,035 corrected). The use of lithium influences the volume of areas associated with memory in the present sample of elderly bipolar patients, possibly due to its neuroprotective effects.

ASSUNTO(S)

aged idoso imagem por ressonância magnética bipolar disorder transtorno bipolar lítio comparative study estudo comparativo magnetic resonance imaging lithium demência dementia

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