Estudo clinicopatologico e imunoistoquimico de prurigo actinico de labio / Clinicopathological and imunohistochemical study af actinic prurigo of lip

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Actinic prurigo (AP) is a specific familial photodermatosis that affects mainly mestizos, who live in many parts of North, Central and South America. AP can be clinically evident at any age, but it starts in infancy, between 6 and 8 years of age. It is more frequent in women. AP affects mainly persons living in regions above one thousand meters sea level. The disease affects mainly sun exposed skin, andclinically it is polymorphic. The objective of this study was to evaluate the clinical, histological and immunohistochemistry characteristics of 43 cases of AP of the lower lip. Sixteen cases were in males and 24 females (62.8%), with mean age of 28.6%. All cases involved the lower lip and other skin sites, but in 17 cases the lesions occurred only in the lower lip (39.54%). Hyperpigmentation, descamation, plaques, ulcers and edema were the main clinical alterations in our series. Microscopically on the superficial epithelial it was found mainly hyperqueratosis, ulceration, vacuolization of the basal and supra basal layer cells and exocytosis. In the subjacent connective tissue predominated a chronic inflammatory process, in many cases rich in lymphoid follicles in various degrees of organization. In none of the cases it was observed elastosis in the connective tissue. Immunohistochemistry markers confirmed that the follicles showed an organization similar to normal follicles. Syndecan-1 was expressed homogenously in the spinous layers of the superficial epithelium, but it was negative in the basal and suprabasal layers. D2-40 was positive in the dendritic cells of the follicular centers and basal cells of the superficial epithelium. Mast cell, eosinophils, and macrophages were found among the plasmatic cells

ASSUNTO(S)

ultraviolet rays dermatitis diagnosis pathology labios - doenças - diagnóstico histology imunohistoquimica labios - inflamação radiação ultravioleta

ACESSO AO ARTIGO

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