Effect of gentamicin treatment on adenylate cyclase and Na+, K+-ATPase activities in renal tissues of rats.
AUTOR(ES)
Queener, S F
RESUMO
Gentamicin (20 mg/kg) treatment of male rats reduced Na+,K+-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=185949Documentos Relacionados
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