EFEITOS DO OLEO ESSENCIAL DE Lippia sidoides Cham. E DO OLEO FIXO DE Caryocar coriaceum Wittm. SOBRE A INFLAMACAO TOPICA E A CICATRIZACAO DE FERIDAS CUTANEAS FORTALEZA-CE 2009

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

01/12/2009

RESUMO

The skin lesions that affect animals are common in veterinary practice. Plants with anti-inflammatory and wound healing activities are being researched as one alternative for treatment of these injuries. The aim of this study was to evaluate the effects of essential oil of Lippia sidoides and fixed oil of Caryocar coriaceum on topical inflammation and skin wound healing in experimental models in vivo. Vegetable oils were purchased commercially in Fortaleza, Ceará, and used for chemical and microbiological analysis. The effect on topical inflammation was evaluated by xylene-induced ear edema model in mice, using topical application of vegetable oils as controls, and dexamethasone and indomethacin as reference drug. To evaluate the wound healing, the excision wound model in rats and mice was used. Experimental wounds were created on the back of the animals and treated topically with ointments containing essential oil L. sidoides and fixed oil C. coriaceum in their formulations. The morphometric analyses of the lesions were performed by digital planimetry, and skin fragments were collected for histological evaluation on days 0, 3, 7, 14 and 21. Essential oil L. sidoides in nature, rich in thymol (70.97%), showed edematogenic effect when applied topically in ear of mice, causing effect similar to xylene (p>0.05), and exhibited a deleterious effect on the acute inflammatory phase of wound healing process. On the other hand, fixed oil C. coriaceum was capable to inhibit the xylene-induced ear edema in 38.01% and 39.20% at times 15 min and 1 h after application phlogistic agent, respectively (p <0.05). Furthermore, the topical administration of fixed oil C. coriaceum ointment 12% accelerated the skin wound healing process (p<0.05), which was confirmed by histological analysis. These effects may be associated to high levels of unsaturated fatty acid omega-9 (57.15%) present in this oil. In conclusion, essential oil L. sidoides, in nature, can be used as phlogistic agent in topical inflammation model. On the other hand, fixed oil C. coriaceum modulates the immune-inflammatory response and cutaneous repair, suggesting a potential therapeutic implication on immune system skin.

ASSUNTO(S)

lippia sidoides caryocar coriaceum inflamação tópica. cicatrização sistema imune da pele outros lippia sidoides caryocar coriaceum topical inflammation wound healing skin immune system

ACESSO AO ARTIGO

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