Efeito de lasalocid-A sobre o fluxo de Ca2+ mitocondrial

AUTOR(ES)
DATA DE PUBLICAÇÃO

1989

RESUMO

A previous communication (PEREIRA DA SILVA et alii, 1984) presented evidence that lasalocid-A, at concentrations far below those required to act as Ca2+ ionophore, significantly inhibited Ca2+ efflux from liver mitochondria. In the present work we have studied the mechanism of this inhibition in liver and heart mitocondria. Firstly it was observed that lasalocid-A, in the range of concentration used in these experiments (0-250nM), promotes the electroneutral exchange of K+ for H+ across the inner mitochondrial membrane and as a consequence can cause important alterations in the values for ?delta?PH and ?delta? U (chemical and electrical components, respectively, of the electrochemical membrane potential (?delta? UH+). The indirect effect of those alterations in the inhibition of mitochondrial Ca2+ release eas ruled out by our experiments which have shown three patters of lasalocid-A effect, depending on the size of the mitochondrial Ca2+ load. ... Note: The complete abstract is available with the full electronic digital thesis or dissertations

ASSUNTO(S)

mitocondria

ACESSO AO ARTIGO

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