Clinical and epidemiological analysis of pregnant women accidentally vaccinated against rubella / "Análise clínico-epidemiológica das gestantes inadvertidamente vacinadas contra a rubéola"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

INTRODUCTION: In the years 1999 and 2000, rubella outbreaks reaching mostly young adults resulted in an increased number of cases of Congenital Rubella Syndrome in Brazil. State Vaccination Campaigns aiming at women at childbearing age were promoted around the country to control the disease, recommending that vaccination of pregnant women should be avoided and pregnancy should be postponed for at least a month after vaccination. Despite the recommendations, 6.473 pregnant women were accidentally vaccinated in the State of São Paulo and therefore sent to reference obstetrical services for prenatal care. A study was conducted to describe the cases assisted at the University of São Paulo, School of Medicine, General Hospital and notified to Public Health and also to obtain information on the pregnancy outcomes. METHODS: This descriptive epidemiological study used notification by the Hospital Epidemiology Service as source of information on pregnant women accidentally vaccinated against rubella that received care from November 2001 to December 2002 at the School of Medicine, General Hospital. The City of São Paulo Newborn Database was searched for pregnancy outcomes. RESULTS: Among the 409 notified cases, 49,1% were women accidentally vaccinated during fist trimester of pregnancy and 26,2% women that became pregnant within less than a month after vaccination. Positive serological tests were found in 16,9% of women during prenatal care. Newborn data base search yielded pregnancy outcome for 63,3%. The findings of 2 cases of Congenital Rubella Syndrome and 1miscarriage cannot be surely attributed to vaccination because immediate previous immunization status was unknown. CONCLUSIONS: The study described the information flow established for an unexpected adverse event and the use of secondary data to improve quality of information. Hospital Epidemiology Services have a fundamental role in connecting health assisting professionals to Public Surveillance Systems and in setting standards for information generated by Health Assistance.

ASSUNTO(S)

congenital/prevention &control rubéola (sarampo alemão)/prevenção &controle sistemas de informação hospitalar/utilização vigilância epidemiológica rubella syndrome rubella/epidemiology síndrome da rubéola congênita/prevenção &controle rubéola (sarampo alemão)/epidemiologia vacina contra rubéola/efeitos adversos hospital information systems/utilization epidemiologic surveillance rubella vacine/adverse effects rubella/ prevention &control

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