Circulating endothelial cells are increased in chronic myeloid leukemia blast crisis
AUTOR(ES)
Godoy, C.R.T., Levy, D., Giampaoli, V., Chamone, D.A.F., Bydlowski, S.P., Pereira, J.
FONTE
Braz J Med Biol Res
DATA DE PUBLICAÇÃO
27/03/2015
RESUMO
We measured circulating endothelial precursor cells (EPCs), activated circulating endothelial cells (aCECs), and mature circulating endothelial cells (mCECs) using four-color multiparametric flow cytometry in the peripheral blood of 84 chronic myeloid leukemia (CML) patients and 65 healthy controls; and vascular endothelial growth factor (VEGF) by quantitative real-time PCR in 50 CML patients and 32 healthy controls. Because of an increase in mCECs, the median percentage of CECs in CML blast crisis (0.0146%) was significantly higher than in healthy subjects (0.0059%, P<0.01) and in the accelerated phase (0.0059%, P=0.01). There were no significant differences in the percentages of CECs in chronic- or active-phase patients and healthy subjects (P>0.05). In addition,
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