Blast crisis in a murine model of chronic myelogenous leukemia.
AUTOR(ES)
Daley, G Q
RESUMO
The P210bcr/abl protein is produced in cells from patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Retroviral transfer of the gene encoding P210bcr/abl into murine bone marrow induces a granulocytic leukemia that models the chronic phase of human CML. We have transferred the leukemic clone to syngeneic animals, albeit with surprising inefficiency, and have observed CML and clonally related acute leukemias of lymphoid or myeloid phenotype in some transplant recipients. These data show that murine CML can result from retroviral transfer of the bcr/abl gene into pluripotent hematopoietic stem cells, that infected clones repopulate poorly after adoptive transfer, and that these clones can give rise to acute leukemia, reflecting evolution to a phase resembling blast crisis in the human disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=53129Documentos Relacionados
- Transforming genes in chronic myelogenous leukemia.
- Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.
- An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.
- Circulating endothelial cells are increased in chronic myeloid leukemia blast crisis
- Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis.