A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.
AUTOR(ES)
Pérez de Castro, I
RESUMO
Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1050236Documentos Relacionados
- Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes
- Association between duration of untreated bipolar disorder and clinical outcome: data from a Brazilian sample
- The dopamine D3 receptor gene: no association with bipolar affective disorder.
- Weak evidence for a relation between bipolar disorder and heterozygous ZNF92 and CLN6 variants
- Anticipation in Swedish families with bipolar affective disorder.
