The dopamine D3 receptor gene: no association with bipolar affective disorder.
AUTOR(ES)
Shaikh, S
RESUMO
Bipolar affective disorder and schizophrenia share many clinical and genetic characteristics, and are thought by some to be different expressions of the same underlying disorder. A recent study showed an excess of homozygosity at a BalI polymorphism in the dopamine D3 receptor gene in schizophrenic patients compared with controls, from two independent centres. We have found no evidence of such an excess in a comparable sample of patients with bipolar affective disorder compared with matched controls. If these findings are confirmed then at least one genetic distinction between these two disorders will have been ascertained and doubt cast upon theories of a common genetic aetiology.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1016339Documentos Relacionados
- Anticipation in Swedish families with bipolar affective disorder.
- Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
- Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
- Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension.
- A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.