Antiparasitic Agents
Mostrando 13-24 de 38 artigos, teses e dissertações.
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13. Why prevent, diagnose and treat congenital toxoplasmosis?
Evidence that prevention, diagnosis and treatment of toxoplasmosis is beneficial developed as follows: anti-parasitic agents abrogate Toxoplasma gondiitachyzoite growth, preventing destruction of infected, cultured, mammalian cells and cure active infections in experimental animals, including primates. They treat active infections in persons who are immune-c
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-03
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14. Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
Nitrocompounds are bioactive molecules used as antibacterial, antiparasitic and antitumoral agents. In the past of years, these molecules have been broadly studied in several fields, such as medicinal chemistry, organic chemistry, biochemical, toxicology and electrochemistry. The nitrocompounds mode of action involves the biotransformation of the nitro group
Química Nova. Publicado em: 2009
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15. Antibacterial activity of free or nanoparticles-loaded violacein / Atividade antimicrobiana da violaceina pura ou em nanoformulação
Since violacein - an antibiotic, antiviral and antiparasitic compound - exhibits poor solubility in water, polymeric nanoparticles containing this compound could improve its solubility in water and biological activities. Therefore, the aim of this work was the preparation and characterization of biodegradable and biocompatible poly-D,L-(lactide-co-glycolide)
Publicado em: 2009
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16. Estudo do processo de eletrodegradação do ivermectin / Study of the electrodegradation of ivermectin
Ivermectin is widely used as an antiparasitic agent against endo and ectoparasites of animaIs and humans; it has a broad spectrum of activity at low dosage levels. Commercial products (Ivomec@, Eqvalan@, Cardomec@~ Mectizan~ usually contain 1% of Ivermectin in glycerol formulation. Ivermectin is a rnixture oftwo homologs containing more than 80% Avermectin B
Publicado em: 2004
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17. Avaliação genotóxica de líquido de vesícula e extrato salino da forma metacestódea de Taenia solium e de agentes antiparasitários benzimidazólicos
Neurocysticercosis (NCC) is the most common parasitic disease of the central nervous system (CNS) caused by cysticerci of the helminth Taenia solium, which is prevalent in developing countries and re-emerging in affluent societies. This helminth has been associated with brain tumours and haematological malignancies in humans. The possible mechanisms leading
Publicado em: 2004
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18. SÃntese e avaliaÃÃo da atividade biolÃgica de novos derivados arilazo-imidazolidÃnicos e arilideno-tiazolidÃnicos frente a vermes adultos de Schistosoma mansoni (Cepa BH)
Several biological activities, includding anti-parasitic, are attributed to imidazolidinic and thiazolodinic nucleous due to their chemical reactivite and, consequently afinity; wich directed us to find new antischistossomal agents. We prepared new 5-arylazo-3-benzyl-4-thioxo-imidazolidin-2-one 8a-d and 5-arylidene-3-(4-bromo-benzyl)-thiazolidine-2,4-dione 1
Publicado em: 2004
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19. In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phenothiazine drugs
Phenothiazine drugs - fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine - were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium falciparum. Aiming to simulate therapeutic schedules, chloroquine was employed at the concentration used for sensitive falciparum malaria treatment and anti-psycho
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-10
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20. Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase
A novel fungal metabolite, apicidin [cyclo(N-O-methyl-l-tryptophanyl-l-isoleucinyl-d-pipecolinyl-l-2-amino-8-oxodecanoyl)], that exhibits potent, broad spectrum antiprotozoal activity in vitro against Apicomplexan parasites has been identified. It is also orally and parenterally active in vivo against Plasmodium berghei malaria in mice. Many Apicomplexa
The National Academy of Sciences of the USA.
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21. Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design*
Cysteine proteases of the papain superfamily are implicated in a number of cellular processes and are important virulence factors in the pathogenesis of parasitic disease. These enzymes have therefore emerged as promising targets for antiparasitic drugs. We report the crystal structures of three major parasite cysteine proteases, cruzain, falcipain-3, and th
American Society for Biochemistry and Molecular Biology.
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22. Role of P Glycoprotein in the Course and Treatment of Encephalitozoon Microsporidiosis
Encephalitozoon microsporidia are obligate intracellular protozoan parasites that proliferate and differentiate within a parasitophorous vacuole inside host cells that are usually epithelial in nature. Isolates of the three species of the Encephalitozoon microsporidia, E. cuniculi, E. hellem, and E. intestinalis, were obtained from AIDS patients and cultured
American Society for Microbiology.
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23. Tetracyclines as antiparasitic agents: lipophilic derivatives are highly active against Giardia lamblia in vitro.
Comparisons of the inhibitory activities of different tetracyclines have been reported for Plasmodium falciparum but no other parasites. The in vitro response of the intestinal parasite Giardia lamblia to six tetracyclines in current use was determined. In addition, the experimental drug thiacycline (EMD 33,330) was evaluated. Three groups were discerned, wi
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24. Virtual Screening of Combinatorial Libraries across a Gene Family: in Search of Inhibitors of Giardia lamblia Guanine Phosphoribosyltransferase
Parasitic protozoa lack the ability to synthesize purine nucleotides de novo, relying instead on purine salvage enzymes for their survival. Guanine phosphoribosyltransferase (GPRT) from the protozoan parasite Giardia lamblia is a potential target for rational antiparasitic drug design, based on the experimental evidence, which indicates the lack of interconv
American Society for Microbiology.