Tetracyclines as antiparasitic agents: lipophilic derivatives are highly active against Giardia lamblia in vitro.
AUTOR(ES)
Edlind, T D
RESUMO
Comparisons of the inhibitory activities of different tetracyclines have been reported for Plasmodium falciparum but no other parasites. The in vitro response of the intestinal parasite Giardia lamblia to six tetracyclines in current use was determined. In addition, the experimental drug thiacycline (EMD 33,330) was evaluated. Three groups were discerned, with representative 50 and 90% inhibitory concentrations of, respectively, 36 and 130 (tetracycline), 6.4 and 22 (doxycycline), and 1.8 and 3.4 (thiacycline) micrograms/ml. These dramatic differences in activity correlate with increased lipophilicity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=172838Documentos Relacionados
- Enhanced antiparasitic activity of lipophilic tetracyclines: role of uptake.
- Small-intestinal factors promote encystation of Giardia lamblia in vitro.
- Efficacies of Zinc-Finger-Active Drugs against Giardia lamblia
- Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro.
- Serum Cohn fraction IV-1 supports the growth of Giardia lamblia in vitro.