Antiparasitic Agents
Mostrando 1-12 de 38 artigos, teses e dissertações.
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1. Synthesis of leading chalcones with high antiparasitic, against Hymenolepis nana, and antioxidant activities
The hymenolepiosis by Hymenolepis nana is a major public health problem in developing countries, and the commercial drugs against this parasitosis are not enough effective. The combination of antiparasitic and antioxidant agents has improved the treatment of some parasitoses. Thus, the development of new cestocidal and antioxidant agents to treat the hymenol
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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2. 1,2,4- and 1,3,4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents
In this review, we present the potential use of the heterocyclic oxadiazole rings in the design and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the four isomeric forms of oxadiazole rings as well as discuss the differences and similarities between them. In addition, we discuss aspects on their reactivity that justify
J. Braz. Chem. Soc.. Publicado em: 2018-03
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3. Silver and Silver Chloride Nanoparticles and their Anti-Tick Activity: a Mini Review
This overview highlights the importance of characterization of biogenic nanoparticles of silver and silver chloride in order to understand the action on ticks or pathogens transmitted by them. These nanoparticles appear as important active principles in this area. They can act against ticks or against major pathogens transmitted by the bite of ticks such as
J. Braz. Chem. Soc.. Publicado em: 2017-06
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4. Biomimetic oxidation studies of monensin A catalyzed by metalloporphyrins: identification of hydroxyl derivative product by electrospray tandem mass spectrometry
Monensin A is an important commercially available natural product isolated from Streptomyces cinnamonensins that shows antibiotic and anti-parasitic activities. This molecule has a significant influence in the antibiotic market, but until now there are no studies on putative metabolite formations. Bioorganic catalysts applying metalloporphyrins and mono-oxyg
Rev. bras. farmacogn.. Publicado em: 09/08/2013
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5. Drimanes from Drimys brasiliensis with leishmanicidal and antimalarial activity
This paper evaluates CHCl3 and CH3OH extracts of the stem bark, branches and leaves of Drimys brasiliensis and drimane sesquiterpenes isolated from the stem bark against strains of Leishmania amazonensis and Leishmania braziliensis promastigotes and Plasmodium falciparum trophozoites. All of the extracts and compounds were tested in cell lines in comparison
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-04
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6. Resolução enantiomérica do secnidazol / Enantiomeric resolution of secnidazole
O secnidazol corresponde à formulação 1-(hidroxipropil)-2-metil-5-nitroimidazol e possui espectro de atividade contra microorganismos anaeróbicos e eficácia no tratamento de amebíase, giardíase, tricomoníase e vaginose bacteriana. Ele é comercializado na forma racêmica, isto é, na proporção 1:1 dos seus enantiômeros R e S. Não é oficial em ne
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012
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7. Antiparasitic bromotyrosine derivatives from the Caribbean marine sponge Aiolochroia crassa
Six bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Aiolochroia crassa: 3-bromo-5-hydroxy-O-methyltyrosine (1), 3-bromo-N,N,N-trimethyltyrosinium (2), 3-bromo-N,N,N,O-tetramethyltyrosinium (3), 3,5-dibromo-N,N,N-trimethyltyrosinium (4), 3,5-dibromo-N,N,N,O-tetramethyltyrosinium (5), and aeroplysinin-1 (6). Structural determinat
Química Nova. Publicado em: 2012
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8. Síntese de novos derivados de 1-(7-cloro-4- Quinolinil)tiossemicarbazidas e Semicarbazidas como potencias agentes Antibacterianos e antiparasitários
This work, entitled Synthesis of novel derivatives of 1-(7-chloro-4- quinolinyl)thiosemicarbazides and semicarbazides as potencial antibacterial and antiparasitic agents describes the synthesis of new derivatives of 1-(7-chloro-4- quinolinyl)thiosemicarbazides and semicarbazides, N-1-substituted pyridine derivatives were also prepared and their evaluation as
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/07/2011
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9. Atividade anticâncer in vitro e in vivo de Psidium guajava L. (nome popular: goiabeira) / Psidium guajava L. (popular name guava) in vitro and in vivo anticancer activity
Anticancer drug research based on screening of natural sources enabled the discovery of several drugs that are used in cancer treatment. This project aimed to evaluate the in vitro and in vivo anticancer activity of Psidium guajava L. (popular name: guava), elected for its ethnopharmacological use for antiparasitic activity. After harvesting, the vegetal mat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/02/2011
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10. Síntese, caracterização e estudo da atividade inibitória de novas dialquilfosforilarilidrazonas sobre o crescimento de tripanossomatídeos
A new series of dialkylphosphorylhydrazones was synthesized through the condensation of aromatic aldehydes with different phosphorylhydrazines. All synthesized compounds were characterized by IR, ¹H-NMR, 13C-NMR and 31P-NMR spectroscopies. The in vitro investigation of the activity of these compounds against Leishmania amazonensis promastigotes and epimasti
Química Nova. Publicado em: 2011
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11. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the available drugs are unsatisfactory. Aromatic compounds represent an important class of DNA minor groove-binding lig
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-05
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12. Análogos fluorescentes de agentes anti-parasitários: interações com agregados anfifílicos / Fluorescent analogues of antiparasitic agents: interactions with amphiphilic aggregates
Esse trabalho é sobre a agregação da droga leishmanicida miltefosina e um análogo fluorescente e sua interação com vesículas fosfolipídicas. A leishmaniose é uma doença tropical causada por diferentes espécies do gênero Leishmania que atinge boa parte do mundo e, nas duas últimas décadas, sua manifestação visceral reapareceu de forma preocupa
Publicado em: 2010