9 10 Dimethyl 1 2 Benzanthracene
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Efeitos do imiquimode e do laser em baixa intensidade (λ660nm) no câncer quimicamente induzido em mucosa oral de hamsters). / Effects of imiquimod and low intensity laser (660nm) on chemo induced cancer in oral mucosa of hamsters.
O objetivo deste estudo foi avaliar o efeito do imiquimode e do laser (.660nm) no câncer quimicamente induzido em mucosa oral de hamsters sírios dourados. Foram utilizados 25 hamsters nos quais as lesões de câncer foram quimicamente induzidas na mucosa jugal direita através de aplicações do carcinógeno DMBA (9,10-Dimetil-1,2-Benzantraceno) três veze
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2010
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2. Evaluation of the tumor inhibitive effect of in natura (Copaifera reticulata) and hand prepared oil in the DMBA-induced oral carcinogenesis model / Avaliação do efeito inibidor tumoral do óleo resina de copaíba in natura (Copaifera reticulata) e manipulado artesanalmente no modelo de carcinogênese bucal experimental DMBA induzida
A Medicina natural tem se apresentado como alternativa para a cura de inúmeras doenças que afetam a população, utilizando-se de plantas da flora brasileira; muito embora ainda não sejam totalmente esclarecidos os princípios ativos, mecanismo de ação e características de citotoxicidade destes produtos. Uma dessas substâncias é um óleo extraído de
Publicado em: 2007
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3. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.
Sulforaphane [1-isothiocyanato-4-(methyl-sulfinyl)butane] was recently isolated from one variety of broccoli as the major and very potent inducer of phase 2 detoxication enzymes in murine hepatoma cells in culture. Since phase 2 enzyme induction is often associated with reduced susceptibility of animals and their cells to the toxic and neoplastic effects of
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4. Acidic pH induces topoisomerase II-mediated DNA damage
Acidic pH plays an important role in various pathophysiological states and has been demonstrated to be carcinogenic in animal models. Recent studies have also implicated acidic pH in the development of preneoplastic Barrett's esophagus in human. However, little is known about the molecular mechanism underlying acidic pH-induced carcinogenesis. In the current
The National Academy of Sciences.
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5. Bombesin antagonist prevents CO2 laser-induced promotion of oral cancer.
We previously reported that CO2 laser incisions in carcinogen-initiated fields promoted cancer development and caused release of growth factors. Here we examined the quantitative and additive properties of this tumor-promoting event and examined whether this promotion could be nullified by treatment with a bombesin antagonist, which down-regulates epidermal
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6. Mutagenic Action, Loss of Transforming Activity, and Inhibition of Deoxyribonucleic Acid Template Activity In Vitro Caused by Chemical Linkage of Carcinogenic Polycyclic Hydrocarbons to Deoxyribonucleic Acid
In a solvent system of 10−2m phosphate buffer (pH 6.8)-ethanol (2:1, v/v) and in an iodine-induced reaction, the polycyclic hydrocarbons [3H]3,4-benzpyrene and [3H]3,4-BP/[3H]9, 10-dimethyl-1,2-benzanthracene (DMBA) can be covalently linked to deoxyribonucleic acid (DNA) at room temperature. By stepwise addition of the hydrocarbon and repeating the reactio
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7. Synergistic effects of bombesin and epidermal growth factor on cancers.
Bombesin and gastrin-releasing peptide act as autocrine mitogens in various cancers. Bombesin antagonist RC-3095 inhibited growth in some cancers and slowed the progression of premalignant lesions, possibly by down-regulating epidermal growth factor (EGF) receptors. Since the EGF receptor mitogen response involves tyrosine kinase stimulation, we tested the h
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8. Peptide analogues alter the progression of premalignant lesions, as measured by Photofrin fluorescence.
Somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 were infused at 2 micrograms per day via miniosmotic pumps implanted s.c. in hamsters with premalignant disease to examine the effect of these peptides on cancer promotion and progression. These analogues have been shown to inhibit growth of certain tumors, especially thos
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9. Studies of the carcinogenesis and tumorigenesis of skin applications of dodecylbenzene on hairless mice.
Dodecylbenzene in various concentrations, dissolved in acetone to a final volume of 50 microliters, was applied twice a week for 78 weeks to the back skin of hairless mice, with or without pretreatment with 51.2 micrograms 9,10-dimethyl-1,2-benzanthracene (DMBA). A negative control group was painted with acetone only and a positive control group was given a