Veratrine
Mostrando 1-12 de 12 artigos, teses e dissertações.
-
1. Uliginosin B, a natural phloroglucinol derivative with antidepressant-like activity, increases Na+,K+-ATPase activity in mice cerebral cortex
ABSTRACT Uliginosin B, a phloroglucinol isolated from Hypericum polyanthemum Klotzsch ex Reichardt, Hypericaceae, has antidepressant-like effect in the forced swimming test in rodents and inhibits monoamines neuronal reuptake without binding to their neuronal carriers. Studies showed the involvement of Na+,K+-ATPase brain activity in depressive disorders, as
Rev. bras. farmacogn.. Publicado em: 2016-10
-
2. Avaliação do mecanismo de ação antidepressiva e estudo da toxicidade oral aguda e de doses repetidas de hypericum polyanthemum em camundongos / Evaluation of the antidepressant mechanism of action and oral toxicity study of Hypericum polyanthemum in mice
O objetivo deste trabalho foi ampliar o estudo do mecanismo de ação antidepressivo de Hypericum polyanthemum (POL) e de seu composto derivado da classe dos floroglucinóis uliginosina B (ULI). Considerando o potencial desta planta para o desenvolvimento de novos fármacos, realizou-se um estudo pré-clínico de toxicidade aguda e doses repetidas de POL em
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
-
3. Ação toxica da veratrina em mitocondrias e no reticulo sarcomplasmatico / Toxic action of veratrine on mitochondria and sarcoplasmatic reticulum
A veratrina, uma mistura de alcalóides obtidos da espécie de planta Shoenocaulon officinale, é uma toxina lipossolúvel que possui como sítio de ação primária os canais de sódiodependentes de voltagem. Recentemente, nossos estudos mostraram que a veratrina pode causar mionecrose e as evidências sugerem que as mitocôndrias e o retículo sarcoplasmá
Publicado em: 2006
-
4. Estudo da interação da veratrina com o musculo esqueletico por metodos histoquimicos, ultraestruturais e bioquimicos
Veratrine, a commercial extract from the South and Central America plant Schoenocaulon officinale (Liliaceae), activates voltage-dependent Na + channels to produce persistent depolarization and an increase in sodium ion penneability in muscle fibers or nerves. The aim of this study was to investigate the effects of the veratrine aIkaloid on skeletal muscle o
Publicado em: 2000
-
5. Intracoronary veratrine attenuates carotid baroreceptor reflex regulation of blood pressure in conscious dogs.
1. The effect of activation of left ventricular cardiac receptors on carotid baroreflex control of blood pressure, heart rate, cardiac output, and total peripheral resistance was determined in conscious dogs. Previous studies in conscious subjects assessed only the effect on baroreflex control of heart rate. 2. Dogs with denervated aortic baroreceptors were
-
6. Lung reflexes and nasal vascular resistance in the anaesthetized dog.
1. In pentobarbitone-anaesthetized dogs the nasal vasculature was perfused on both sides, and nasal vascular and airflow resistances were measured together with blood pressure, heart rate and tidal airflow. 2. Capsaicin was injected intravenously to stimulate lung C-fibre receptors, and veratrine to stimulate pulmonary stretch receptors and cardiac receptors
-
7. Lung and cardiac reflex actions on the tracheal vasculature in anaesthetized dogs.
1. With pentobarbitone-anaesthetized dogs, the cranial tracheal arteries have been independently perfused on both sides, to measure vascular resistance. Blood pressure and contractions of tracheal muscle were also measured. 2. Capsaicin was injected intravenously to stimulate lung C-fibre receptors. In breathing and in paralysed artificially ventilated dogs
-
8. Gadolinium inhibits mechanoelectrical transduction in rabbit carotid baroreceptors. Implication of stretch-activated channels.
Gadolinium (Gd3+) has been shown to prevent mechanoelectrical transduction believed to be mediated through stretch-activated channels. We investigated the possible role of Gd(3+)-sensitive channels in mediating baroreceptor activity in the carotid sinus of rabbits. Baroreceptor activity induced by a ramp increase of carotid sinus pressure was reduced signifi
-
9. Effects of capsaicin applied perineurally to the vagus nerve on cardiovascular and respiratory functions in the cat.
The effects of capsaicin applied perineurally to the cervical vagus nerves have been studied on cardiovascular and respiratory functions in urethane anaesthetized cats. Application of capsaicin resulted in a moderate but significant decrease in the mean arterial blood pressure and in changes of the heart rate whose direction and magnitude depended on the ini
-
10. Evidence for the identification of synaptic transmitters released by photoreceptors of the toad retina.
1. When toad retinae were incubated with veratrine, kainic acid, and L-alpha-aminoadipic acid, photoreceptor cells survived and most other neurones died. This preparation of 'isolated' photoreceptor cells accumulated radioactive molecules from the incubation medium and metabolized these into labelled compounds. When a preparation was placed on a filter and s
-
11. Calcium-independent release of GABA from isolated horizontal cells of the toad retina.
1. When toad retinae were incubated first with veratrine, then with antibodies that reacted with the outer segments of photoreceptors, and finally with complement, horizontal cells survived and most other neurones died. This preparation of 'isolated' horizontal cells accumulated radioactive GABA from the incubation medium. The subsequent release of radioacti
-
12. The responses of duodenal tension receptors in sheep to pentagastrin, cholecystokinin and some other drugs.
The proposal that some post-prandially released alimentary hormones modify ingestive behaviour and gastric emptying by altering impulse activity in alimentary enteroceptors has been tested using a number of gastrointestinal peptide hormone analogues. These and other drugs were applied to single-unit afferent preparations of duodenal tension receptors in chlo