Toxicity Testing
Mostrando 1-12 de 100 artigos, teses e dissertações.
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1. The Importance of Otoneurological Evaluation in Brazilian Workers Exposed to Pesticides: A Preliminary Study
Abstract Introduction Agrochemicals, also known as pesticides, are widely used in agriculture and in public health. They are organic and inorganic chemical substances with a high level of toxicity not only for the environment, but also for human health. Objective To verify findings on labyrinthine assessment in endemic disease control agents, and to reco
Int. Arch. Otorhinolaryngol.. Publicado em: 25/11/2019
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2. Assessment of the non-surgical treatment of patients with rectal cancer who underwent neoadjuvant treatment with chemotherapy and radiotherapy at the oncology department
RESUMO Objetivo: Descrever os resultados parciais de estudo em pacientes com câncer de reto submetidos a tratamento neoadjuvante com quimioterapia e radioterapia quanto à taxa resposta clínica completa, sobrevida livre de doença, função anorretal e qualidade de vida. Material e métodos: Estudo prospectivo desde junho 2015 até junho de 2018, em paci
J. Coloproctol. (Rio J.). Publicado em: 13/06/2019
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3. In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new therapeutic interventions. Because translocator protein (TSPO) levels are reduced in Leishmania amazonen
Mem. Inst. Oswaldo Cruz. Publicado em: 05/02/2018
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4. In vitro antifungal activity of Myracrodruon urundeuva Allemão against human vaginal Candida species
ABSTRACT Myracrodruon urundeuva is a plant native to Brazil, which is used by the indigenous population for the treatment of candidiasis. The aims of this study were to evaluate the antifungal activity of extract against human vaginal Candida species and evaluate the possible toxicological activities of M. urundeuva. Initially, ethanol extracts, ethyl acetat
An. Acad. Bras. Ciênc.. Publicado em: 24/07/2017
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5. Inhibition of HMG-CoA reductase activity and cholesterol permeation through Caco-2 cells by caffeoylquinic acids from Vernonia condensata leaves
ABSTRACT The aim of this study was to provide scientific knowledge to support the use of Vernonia condensata Baker, Asteraceae, beverages for their alleged hypocholesterolemic properties by testing their action as HMG-CoA reductase inhibitors and their capacity to lower dietary cholesterol permeation. Chlorogenic acid, and other caffeoylquinic acids derivati
Rev. bras. farmacogn.. Publicado em: 2016-12
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6. Sida tuberculata (Malvaceae): a study based on development of extractive system and in silico and in vitro properties
Sida tuberculata (Malvaceae) is a medicinal plant traditionally used in Brazil as an antimicrobial and anti-inflammatory agent. Here, we aimed to investigate the different extractive techniques on phytochemical parameters, as well as to evaluate the toxicity and antioxidant capacity of S. tuberculata extracts using in silico and in vitro models. Therefore, i
Braz J Med Biol Res. Publicado em: 11/07/2016
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7. Cocaine/levamisole-induced systemic vasculitis with retiform purpura and pauci-immune glomerulonephritis
Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia,
Braz J Med Biol Res. Publicado em: 26/04/2016
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8. The efficacy of 2-nitrovinylfuran derivatives againstLeishmania in vitro and in vivo
Despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. The wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against Trichomonas vaginalis and other protozoa. Thus, the aim of th
Mem. Inst. Oswaldo Cruz. Publicado em: 24/03/2015
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9. Study of the antimicrobial activity of metal complexes and their ligands through bioassays applied to plant extracts
The appearance of resistant bacteria was found to reduce the efficiency of antimicrobial therapies with the current antibiotics, thereby increasing the need for more efficient drugs for the treatment of infections. Several studies have demonstrated an increase in antimicrobial activity following the interaction of several compounds with metal ions. The prese
Rev. bras. farmacogn.. Publicado em: 2014-06
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10. Alternative methods in toxicity testing: the current approach
Métodos alternativos estão sendo desenvolvidos para a redução, o refinamento e a substituição (3R) do número de animais utilizados em experimentos, visando ao seu bem-estar. Esses testes alternativos baseiam-se no princípio dos 3R e esforços têm sido empregados para que sejam validados. Na Europa, diversas metodologias já foram implantadas tais co
Braz. J. Pharm. Sci.. Publicado em: 2014-03
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11. Comparison of fibrin adhesives prepared by 3 different methods
INTRODUCTION: Fibrin tissue adhesive, which has applications in several areas of medicine, can be prepared by different methods. Aim: To compare fibrin tissue adhesives prepared by 3 different methods. METHOD: In this prospective experimental laboratory study, fibrin tissue adhesives prepared by the use of plasma fibrinogen (group 1), cryoprecipitation (grou
Int. Arch. Otorhinolaryngol.. Publicado em: 2013-03
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12. Eco/genotoxicidade do corante comercial CI Disperse Red 1 e seus subprodutos clorados / Eco/genotoxicity of commercial dye CI Disperse Red 1 and chlorinated by-products
Cerca de 70% dos corantes utilizados em indústrias têxteis são corantes do tipo azo, que se caracterizam pelo grupo -N=N- ligado a sistemas aromáticos, sendo que a função azo inclui os principais tipos de corantes. A eliminação da cor no efluente é um grande desafio para o setor têxtil, já que, aproximadamente, 15% da produção mundial de corante
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012