Topoisomerase
Mostrando 1-12 de 1108 artigos, teses e dissertações.
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1. The effect of genistein on cisplatin induced ototoxicity and oxidative stress
Resumo DESTAQUES A cisplatina é um agente antineoplásico usado em lesões malignas. A ototoxicidade da cisplatina é geralmente bilateral, irreversível e progressiva. A genisteína é um fitoestrógeno. A genisteína funciona como antioxidante e inibidor do ciclo celular ao inibir a topoisomerase do DNA. A genisteína apresentou efeitos positivos s
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022
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2. Diacetate Naphthoquinone Derivatives Tethered to 1,2,3-Triazoles: Synthesis and Cytotoxicity Evaluation in Caco-2 Cells
Acetylated compounds prepared from naphthoquinones have been reported as antitumoral prodrugs. Exploring the synthetic versatility of the naphthoquinone and triazolic nuclei, herein we report a simple and efficient synthetic route to prepare a series of sixteen prodrugs prototype of 1,2,3-triazoles-naphthoquinodoic acetyl derivatives. The compounds 10a-10h a
Journal of the Brazilian Chemical Society. Publicado em: 2022
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3. Antitumor activity of irinotecan with ellagic acid in C6 glioma cells
SUMMARY OBJECTIVE: Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cel
Revista da Associação Médica Brasileira. Publicado em: 2022
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4. Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoisomerase IB
Herein we present four new ruthenium(II) complexes: [Ru(mtz)2(dppb)] (1), [Ru(mmi)2(dppb)] (2), [Ru(dmp)2(dppb)] (3), and [Ru(mpca)2(dppb)] (4), where mtz = 2-mercaptothiazoline; mmi = 2-mercapto-1-methyl-imidazole; dmp = 4,6-diamino-2-mercaptopyrimidine; mpca = 6-mercaptopyridine-3-carboxylic acid; dppb = 1,4-bis(diphenylphosphino)butane. In vitro cell cult
J. Braz. Chem. Soc.. Publicado em: 2020-03
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5. Synthesis of New trans-Dehydrocrotonin Nitrogenated Derivatives and their Cytotoxic and DNA-Topoisomerase I Inhibitory Activities
A new series of 19-nor-clerodane diterpene derivatives was synthesized from the natural trans-dehydrocrotonin obtained from stem barks of Croton cajucara (Euphorbiaceae), a native medicinal plant of the Brazilian Amazon. The new derivatives were obtained by changes in the ketone moiety of trans-dehydrocrotonin leading to nitrogenated derivatives which are: t
J. Braz. Chem. Soc.. Publicado em: 2018-01
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6. Isolation and characterization of 2-hydroxy-9,10-anthraquinone from Streptomyces olivochromogenes (ERINLG-261) with antimicrobial and antiproliferative properties
Abstract Currently Streptomyces is one of the most important antibiotic producing microorganisms against several diseases. In the present study Streptomyces olivochromogenes ERINLG-261 was isolated from the soil samples of the Mudumalai hills, Western Ghats, India. Morphological, physiological, biochemical and 16S rRNA studies strongly suggested that this is
Rev. bras. farmacogn.. Publicado em: 2016-06
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7. The Octahydroindene Carboxyl Substructure from Dihydrobetulinic Acid is Essential to Inhibit Topoisomerase IB from Leishmania donovani
The dihydrobetulinic acid is a known competitive inhibitor of topoisomerase IB from Leishmania donovani, a validated target for developing new antileishmanial drugs. However, its binding mode and interaction pocket have not been established yet. We combined docking and molecular dynamics simulations to identify the most probable binding pocket. Our best mode
J. Braz. Chem. Soc.. Publicado em: 2016-03
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8. Synthesis, Antitumor Activity and Docking of 2,3-(Substituted)-1,4-Naphthoquinone Derivatives Containing Nitrogen, Oxygen and Sulfur
Eleven 2,3-(substituted)-1,4-naphthoquinone derivatives were synthesized in yields ranging from 52-89%. These derivatives were evaluated for their cytotoxic effects on human lungs (H460), triple-negative breast (MDA-MB-231) and ovarian (A2780) cancer cell lines. Compounds 5f and 8 showed IC50values of 3.048 × 10-5 mol L-1 and 4.24 × 10-6 mol L-1 for H460;
J. Braz. Chem. Soc.. Publicado em: 2015-09
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9. Gene homozygosis and mitotic recombination induced by camptothecin and irinotecan in Aspergillus nidulans diploid cells
A recombinação mitótica é um processo com participação na carcinogênese e com capacidade de induzir perda genética através da perda da heterozigosidade. Os potenciais recombinagênicos de duas drogas anticancerígenas, camptotecina (CPT) e irinotecan (CPT-11), caracterizadas como inibidores da DNA-Topoisomerase I, foram avaliados no presente estudo,
An. Acad. Bras. Ciênc.. Publicado em: 21/10/2014
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10. Efficient one pot synthesis of xanthene-triazole-quinoline/phenyl conjugates and evaluation of their antimicrobial activity
Novos conjugados xanteno-triazol-quinolina/fenila foram sintetizados via condensação ecologicamente amigável one pot de três componentes, 12-aril-2-hidroxi-tetrahidrobenzo[a]xanteno-11-ona, brometo propargílico e 4-azido-7-cloroquinolina/fenil azida usando polietilenoglicol 400 (PEG-400) como meio de reação, com o intuito de explorar seu efeito no cre
J. Braz. Chem. Soc.. Publicado em: 2014-07
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11. Ouratea genus: chemical and pharmacological aspects
Ouratea and the other genera of the Ochnaceae family are a rich source of flavonoids and biflavonoids. These can be used as chemotaxonomic markers of Ouratea. Some biflavonoids, as well as extracts of the Ouratea species show important biological activities, such as antitumour, antiviral, vasodilation, antimicrobial and DNA topoisomerase inhibition. On the
Rev. bras. farmacogn.. Publicado em: 2014-01
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12. IV Consenso Brasileiro para pesquisa de autoanticorpos em células HEp-2
Objetivo: O IV Consenso Brasileiro para Pesquisa de Autoanticorpos em Células HEp-2 (FAN) realizado em Vitória (ES), no dia 18 de setembro de 2012, objetivou discutir estratégias e recomendações relacionadas ao procedimento técnico, à padronização e à interpretação dos resultados da pesquisa de autoanticorpos em células HEp-2. Métodos: Pa
Rev. Bras. Reumatol.. Publicado em: 2014-01