Thyroxine Binding Globulin
Mostrando 1-12 de 57 artigos, teses e dissertações.
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1. Avaliação tireoidiana de pacientes infectados pelo vírus da hepatite C: correlação com polimorfismos do gene CTLA4 / Thyroid evaluation of patients infected by hepatitis C virus: correlation with polymorphisms of CTLA4 gene
INTRODUÇÃO: Manifestações auto-imunes são frequentes na infecção pelo vírus da hepatite C (VHC). Apesar da associação com doenças auto-imunes de tireóide (DAIT) ser controversa, sabe-se que distúrbios tireoidianos podem surgir ou piorar com tratamento com IFN e ribavirina. Os objetivos deste estudo foram avaliar a função tireoidiana em pacient
Publicado em: 2010
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2. Structural studies of the thyroid receptor (TR) and homology modeling of the thyroxine binding globulin (TBG) / Estudos estruturais do receptor do hormônio tireoidiano (hTR) e modelagem por homologia da globulina de ligação à tiroxina (TBG)
The thyroid hormones are involved in various regulatory effects, on diverse organs. Their fluctuations on the body are related to clinical scenarios of great relevance. This work deals with the study of two proteins which are directly related to the regulatory system associated to these hormones. The first one is the thyroxine-binding globulin (TBG), respons
Publicado em: 2005
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3. Definição de valores normais de tiroxina livre durante a gravidez
A gravidez é acompanhada por uma série de modificações fisiológicas que incluem uma elevação significativa da globulina ligadora de tiroxina (Thyroxine-Binding Globulin, TBG). Tal elevação interfere nos níveis séricos totais da tiroxina (T4) e corrobora a utilização da medida de tiroxina livre (T4L), em conjunto com a dosagem de TSH, como métod
Arquivos Brasileiros de Endocrinologia & Metabologia. Publicado em: 2004-04
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4. Desenvolvimento de ensaio imunofluorométrico para a medida da globulina ligadora de tiroxina (thyroxine-binding globulin, TBG) e sua aplicação em casos de deficiência desta proteína
A globulina ligadora de tiroxina (thyroxine-binding globulin, TBG) é a principal transportadora de hormônios tiroidianos no soro. Variações na concentração sérica de TBG determinam variações proporcionais nas concentrações séricas totais de T4 e T3, sem implicar alterações de função, desde que a fração livre permaneça normal. Várias condi
Jornal Brasileiro de Patologia e Medicina Laboratorial. Publicado em: 2002
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5. Effects of Norethandrolone on the Transport and Peripheral Metabolism of Thyroxine in Patients Lacking Thyroxine-Binding Globulin: OBSERVATIONS ON THE PHYSIOLOGICAL ROLE OF THYROXINE-BINDING PREALBUMIN
Studies of the effect of norethandrolone on the transport and peripheral metabolism of thyroxine were carried out in four patients lacking thyroxine-binding globulin. Before norethandrolone administration, values for serum protein-bound iodine (PBI) were decreased (1.8 ±0.5 μg/100 ml) and the proportion of free thyroxine increased (0.036 ±0.008%). As a re
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6. DISPLACEMENT OF THYROXINE FROM HUMAN THYROXINE-BINDING GLOBULIN BY ANALOGUES OF HYDANTOIN. STERIC ASPECTS OF THE THYROXINE-BINDING SITE*
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7. Familial thyroxine-binding globulin deficiency: search for linkage with Xg blood groups
Serum thyroxine-binding globulin (TBG), thyroxine, and thyrotrophin were estimated in members of a family with TBG deficiency. Xga red cell antigen status was also studied. TBG deficiency appeared to be inherited as an X-linked condition. Four male members of the family showed absent TBG and seven heterozygous women showed intermediate TBG levels. Five infor
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8. Study of Four New Kindreds with Inherited Thyroxine-Binding Globulin Abnormalities POSSIBLE MUTATIONS OF A SINGLE GENE LOCUS
Five families with inherited thyroxine-binding globulin (TBG) abnormalities were studied. On the basis of serum thyroxine (T4)- binding capacity of TBG in affected males, three family types were identified: TBG deficiency, low TBG, and high TBG capacity. In all families evidence for X-linked inheritance was obtained and in one family all criteria establishin
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9. Thyroxine Turnover and Transport in Laennec's Cirrhosis of the Liver*
Studies of the metabolism of thyroxine in 14 cases of cirrhosis revealed a variety of deviations from normal. In addition to radiothyroxine turnover studies, determinations were made of the free thyroxine fractions and free thyroxine iodine concentrations in serum (magnesium precipitation method) as well as the maximal binding capacities of thyroxine-binding
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10. Salicylate-induced increases in free triiodothyronine in human serum: Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin
Addition of sodium salicylate to human serum at concentrations often obtained during aspirin therapy causes 100-200% increases in free triiodothyronine (T3) and free thyroxine (T4) as estimated by ultrafiltration. The increase in free T3 was unexpected since previous data had suggested that salicylate inhibits binding of T4 only to thyroxine-binding prealbum
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11. The kinetics of distribution between plasma and liver of 131-I-labeled L-thyroxine in man: observations of subjects with normal and decreased serum thyroxine-binding globulin.
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12. Familial abnormalities of thyroxine binding proteins: some problems of recognition and interpretation.
A three generation family study was carried out after inappropriate treatment with radioactive iodine of a 50 year old woman with a raised serum total thyroxine concentration and free thyroxine index. Subsequent investigations showed that she and five members of her family had raised thyroxine binding globulin concentrations. Free thyroxine and free triiodot