Development and evaluation of a hydrophilic matrix as a buccoadhesive system containing diclofenac sodium

The aim of this work was to study the development and evaluation of a hydrolphilic matrix as a buccoadhesive system containing diclofenac sodium. Eleven formulations were prepared containing the following bioadhesive polymers: hydroxylpropylmethylcellulose, polycarbophil, guar gum and xanthan gum individually and in combination. All the formulations were evaluated for the swelling index, adhesive index, and the time of adhesive and drug release profile (%). The results showed that the formulations that presented the most swelling index were the F3 (PAA/GX) and F6 (GG/GX). The smaller index swe...