Autosomal dominant polycystic kidney disease: possible influences of single nucleotide polymorphism in cytokine genes; Doença renal policística autossômica dominante: possíveis influências de polimorfismos de um único nucleotídeo em genes de citocinas

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited diseases in adults and is caused by mutations in one of two genes, PKD1 or PKD2, which result in accumulation of cysts in the kidneys that can lead to a loss of function. Is the third leading cause of chronic kidney disease (CKD) stage 5. Inflammation has been considered one of the responsible for the progression of CKD. Cytokines act directly in this process by increasing or decreasing the inflammatory response. The stimulation of these cytokines is associated with variants in cytokine genes. These variants may ...

• Assuntos:

  • cytokines
  • autosomal dominant polycystic kidney disease
  • doença renal policística autossômica dominante
  • inflammation
  • chronic kidney failure
  • snp
  • doença renal crônica
  • citocina