Telomeres
Mostrando 1-12 de 659 artigos, teses e dissertações.
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1. Association between leukocyte telomere length and sex by quantile regression analysis
ABSTRACT Introduction: Telomere length (TL) is a biomarker of cellular proliferative history. In healthy individuals, leukocyte TL shortens with age and associates with the lifespan of men and women. However, most of studies had used linear regression models to address the association of the TL attrition, aging and sex. Methods: We evaluated the associatio
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. Telomere length: biological marker of cellular vitality, aging, and health-disease process
SUMMARY The aging process occurs due to the decline of vital physiological functions and adaptability of the body, being influenced by genetics and lifestyle. With advances in genetics, biological aging can be calculated by telomere length. Telomeres are regions at the ends of chromosomes that play a role in the maintenance and integrity of DNA. With biologi
Rev. Assoc. Med. Bras.. Publicado em: 2021-02
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3. Non-random distribution of microsatellite motifs and (TTAGGG)n repeats in the monkey frog Pithecopus rusticus (Anura, Phyllomedusidae) karyotype
Abstract The monkey frog, Pithecopus rusticus (Anura, Phyllomedusidae) is endemic to the grasslands of the Araucarias Plateau, southern Brazil. This species is known only from a small population found at the type locality. Here, we analyzed for the first time the chromosomal organization of the repetitive sequences, including seven microsatellite repeats and
Genet. Mol. Biol.. Publicado em: 13/01/2020
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4. Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TE
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-08
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5. Telomere length and hTERT in mania and subsequent remission
Objective: The findings of telomere length (TL) studies in bipolar disorder (BD) are controversial. The aim of the present study was to detect TL, human telomerase reverse transcriptase (hTERT), and brain derived neurotrophic factor (BDNF) in severe mania and subsequent remission. Methods: Twenty-one medication-free male patients and 20 age and gender matc
Rev. Bras. Psiquiatr.. Publicado em: 06/07/2017
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6. Telomere length correlates with disease severity and inflammation in sickle cell disease
ABSTRACT Background: Telomeres, the ends of linear chromosomes, shorten during mitotic cell division and erosion may be aggravated by inflammation or proliferative and oxidative stress. As the bone marrow is under hyperproliferative pressure in sickle cell disease and several tissues are submitted to chronic inflammation, this study sought to determine the
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-06
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7. Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic clinical entity characterized by the proliferation of monoclonal B cells not meeting the diagnosis criteria for chronic lymphocytic leukemia (CLL). MBL may precede the development of CLL, but the molecular mechanisms responsible for disease progression and evolution are not completely known. Telomeres
Braz J Med Biol Res. Publicado em: 13/04/2017
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8. Characterization of anti-silencing factor 1 in Leishmania major
Anti-silencing factor 1 (ASF1) is a histone chaperone that contributes to the histone deposition during nucleosome assembly in newly replicated DNA. It is involved in chromatin disassembly, transcription activation and in the cellular response to DNA damage. In Leishmania major the ASF1 gene (LmASF1) is located in chromosome 20 and codes for a protein showin
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-05
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9. Cytogenetic and morphological diversity in populations of Astyanax fasciatus (Teleostei, Characidae) from Brazilian northeastern river basins
In the present work, morphometric and cytogenetic analyses were carried out in populations of the fish Astyanax fasciatus (Characidae) from Contas and Recôncavo Sul River basins (State of Bahia, Brazil), providing new data on the genetic structure of this species along the region. Based on morphologic measurements, we observed that populations from the same
Genetics and Molecular Biology. Publicado em: 2008
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10. Cytogenetic markers as diagnoses in the identification of the hybrid between Piauçu (Leporinus macrocephalus) and Piapara (Leporinus elongatus)
The genetic monitoring of interspecific hybrids involves the application of methodologies able to provide an easy and indubitable genetic characterization of both parental and hybrid individuals. In the present work, cytogenetic techniques were used to identify a hybrid lineage of "Piaupara" in order to caracterize them in relation to the parental species, L
Genetics and Molecular Biology. Publicado em: 2008
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11. Telomere length measurements on Human T-cell leukemia virus type I (HTLV-I) infected cells using fluorescence in situ hybridization and flow cytometry (Flow-FISH) / Avaliação do comprimento dos telômeros em células infectadas pelo vírus HTLV-I utilizando a técnica hibridização in situ fluorescente e citometria de fluxo (Flow-FISH)
INTRODUCTION: Adult T-cell Leukemia/Lymphoma (ATL) is a chronic lymphproliferative disease with clonal transformation predominantly of the TCD4+ lymphocytes, caused by the Human T lymphotropic virus type-I (HTLV-I). ATL develops itself in 3-5% of HTLV-I carriers after a long period of clinical latency accompanied by clonal expansion of the infected lymphocyt
Publicado em: 2008
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12. Characterization of the in vivo telomeric single-strand binding proteins from Leishmania amazonensis / Caracterização de proteinas que se associam in vivo com a simples-fita telomerica de Leishmania amazonensis
ormado.
Publicado em: 2007