Tail Suspension
Mostrando 1-12 de 37 artigos, teses e dissertações.
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1. Anxiolytic-like and proneurogenic effects of Trichilia catigua ethyl-acetate fraction in mice with cerebral ischemia
Abstract Trichilia catigua A. Juss., Meliaceae, known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, we have demonstrated that T. catigua ethyl-acetate fraction exerted antidepressive-like effects in mice. Affective-like symptoms are also well recognized outcome of cerebral ischemia in clini
Rev. bras. farmacogn.. Publicado em: 09/12/2019
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2. Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress
The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and 50 mg/kg) significantly increased sucrose consumption a
Braz J Med Biol Res. Publicado em: 19/06/2019
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3. Uliginosin B, a natural phloroglucinol derivative with antidepressant-like activity, increases Na+,K+-ATPase activity in mice cerebral cortex
ABSTRACT Uliginosin B, a phloroglucinol isolated from Hypericum polyanthemum Klotzsch ex Reichardt, Hypericaceae, has antidepressant-like effect in the forced swimming test in rodents and inhibits monoamines neuronal reuptake without binding to their neuronal carriers. Studies showed the involvement of Na+,K+-ATPase brain activity in depressive disorders, as
Rev. bras. farmacogn.. Publicado em: 2016-10
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4. High-impact exercise in rats prior to and during suspension can prevent bone loss
High-impact exercise has been considered an important method for treating bone loss in osteopenic experimental models. In this study, we investigated the effects of osteopenia caused by inactivity in femora and tibiae of rats subjected to jump training using the rat tail suspension model. Eight-week-old female Wistar rats were divided into five groups (n=10
Braz J Med Biol Res. Publicado em: 02/02/2016
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5. Analysis of fracture healing in osteopenic bone caused by disuse: experimental study
Osteoporosis has become a serious global public health issue. Hence, osteoporotic fracture healing has been investigated in several previous studies because there is still controversy over the effect osteoporosis has on the healing process. The current study aimed to analyze two different periods of bone healing in normal and osteopenic rats. Sixty, 7-week-o
Braz J Med Biol Res. Publicado em: 02/02/2016
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6. Behavioural alterations are independent of sickness behaviour in chronic experimental Chagas disease
The existence of the nervous form of Chagas disease is a matter of discussion since Carlos Chagas described neurological disorders, learning and behavioural alterations in Trypanosoma cruzi-infected individuals. In most patients, the clinical manifestations of the acute phase, including neurological abnormalities, resolve spontaneously without apparent conse
Mem. Inst. Oswaldo Cruz. Publicado em: 11/12/2015
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7. Evaluation of postpartum behaviour in rats treated with Hypericum perforatum during gestation
Gestational depression is detrimental to the health of the mother and the offspring and contributes to the appearance of depressive and anxiety symptoms during the postnatal period. Traditional antidepressants have undesirable side effects when utilised during gestation, but Hypericum perforatum has been characterised as an efficient and safe antidepressant
Rev. bras. farmacogn.. Publicado em: 2013-10
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8. Animal models as tools to study the pathophysiology of depression
The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression. A basic understanding of the underlying disease processes in depression is lacking; therefore, recreating the disease in animal models is not possible. Popular current models
Rev. Bras. Psiquiatr.. Publicado em: 2013
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9. AVALIAÇÃO DO POTENCIAL EFEITO ANTIDEPRESSIVO DO 2-BFI, LIGANTE IMIDAZOLÍNICO I2, EM CAMUNDONGOS. / EVALUATION OF THE POTENTIAL ANTIDEPRESSANT-LIKE EFFECT OF IMIDAZOLINE I2 2-BFI IN MICE.
A depressão é uma doença psiquiátrica complexa, crônica e incapacitante, que acarreta um alto custo social. Dentre as diversas classes de antidepressivos encontram-se os inibidores da monoamina oxidase-A (MAO-A), que reduzem o metabolismo das monoaminas. Um sítio importante para a regulação da MAO-A é o sítio imidazolínico I2. Recentemente, foi de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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10. Desenvolvimento de um sistema modificado de suspensão do rato pela cauda, como modelo de osteopenia / Development of a modified system of tail suspension of the rat as a model of osteopenia.
Introdução: A suspensão do rato pela cauda é método usado para simular os efeitos da microgravidade e hipoatividade física sobre o sistema musculoesquelético e outros sistemas. O método convencional usa a tração cutânea para a fixação da cauda do animal ao sistema de suspensão, sendo idealmente aplicado durante até três semanas. Depois desse
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/08/2011
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11. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO / ANTIDEPRESSANT-LIKE PHARMACOLOGICAL PROFILE OF 3-(4- FLUOROPHENYLSELENYL)-2,5-DIPHENYLSELENOPHENE: INVOLVEMENT OF SEROTONERGIC SYSTEM
Depression is a serious, recurrent and incapacitating psychiatric condition with a heavy social burden. The pharmacological approach to this disorder employs therapy with antidepressant drugs, which have side effects and numerous limitations. In view of the promising pharmacological properties of containing-selenium molecules, this study evaluated the effect
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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12. The effect of microgravity on tissue structure and function of rat testis
To explore whether an environment of weightlessness will cause damage to the reproductive system of animals, we used the tail-suspension model to simulate microgravity, and investigated the effect of microgravity on the tissue structure and function of the testis in sexually mature male rats. Forty-eight male Wistar rats weighing 200-250 g were randomly assi
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-12