Synthetic Vaccine
Mostrando 1-12 de 287 artigos, teses e dissertações.
-
1. Effects of (-)-6,6'-dinitrohinokinin on adult worms of Schistosoma mansoni: a proteomic analyses
Abstract Schistosomiasis, a chronic disease that affects million people worldwide, is caused by trematode flukes of the genus Schistosoma. The lack of an anti-schistosomiasis vaccine and massive monotherapy with praziquantel reinforces the need for search and development of new therapeutic drugs. Recently, we demonstrated that the essential oil of Piper cube
Rev. bras. farmacogn.. Publicado em: 2016-06
-
2. A Review of Approaches Targeting the Replacement of Coccidiostat Application in Poultry Production
ABSTRACT The classical and the most commonly used approach for the prevention of coccidiosis in chickens is the incorporation of synthetic coccidiostats into their feed during the first weeks of their life. This approach has been challenged by consumers, objecting against residual antimicrobials and drug resistant microorganisms that may contaminate poultry
Rev. Bras. Cienc. Avic.. Publicado em: 2015-12
-
3. Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax
The PfCLAG9 has been extensively studied because their immunogenicity. Thereby, the gene product is important for therapeutics interventions and a potential vaccine candidate. Antibodies against synthetic peptides corresponding to selected sequences of the Plasmodium falciparum antigen PfCLAG9 were found in sera of falciparum malaria patients from Rondônia,
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-02
-
4. A revacinaÃÃo com a bcg modula a produÃÃo de citocinas frente a antÃgenos do Mycobacterium leprae, em contatos menores de 15 anos de pacientes com hansenÃase. / Revaccination with BCG modulates cytokine production against antigens of Mycobacterium leprae in contacts under 15 years of leprosy patients.
Studies in different populations have shown that vaccination with BCG provides partial protection against leprosy. However, need of boost BCG vaccination and your impact in response immune against antigens of Mycobacterium leprae is poorly understood, mainly in children who are contacts of these patients with leprosy, and constitute population of risk for il
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/05/2010
-
5. Evaluation of local immune response to Fasciola hepatica experimental infection in the liver and hepatic lymph nodes of goats immunized with Sm14 vaccine antigen
Protection against Fasciola hepatica in goats immunized with a synthetic recombinant antigen from Schistosoma mansoni fatty acid-binding protein 14 (rSm14) was investigated by assessing worm burdens, serum levels of hepatic enzymes, faecal egg count and hepatic damage, which was evaluated using gross and microscopic morphometric observation. The nature of th
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-08
-
6. Development of a therapeutic vaccine against HPV16 / Desenvolvimento de vacina terapêutica contra HPV16
Cervical cancer is the second most common cancer among women worldwide. Most cases (83%) occur in developing countries, where they are found in relatively advanced stages and, consequently, the median survival is about 49% after five years. Therefore, an effective vaccine against HPV infections can lead to control of cancer of the cervix. Although preventabl
Publicado em: 2010
-
7. Avaliação da imunogenicidade de epitopos de células T das proteínas Sm14 e paramiosina do schistosoma mansoni em modelo murino.
Sm14 and paramyosin are S. mansoni antigens able to induce partial protection in the murine model, and are recognized by individuals resistant to S. mansoni. Recently our group has identified Sm14 and paramyosin epitopes preferentially recognized by PBMC of S. mansoni resistant individuals [Sm14 (32-48), Sm14 (53-69), Para (6-22), Para (210-226), Para (355-3
Publicado em: 2008
-
8. Plasmodium vivax thrombospondin related adhesion protein: immunogenicity and protective efficacy in rodents and Aotus monkeys
The thrombospondin related adhesion protein (TRAP) is a malaria pre-erythrocytic antigen currently pursued as malaria vaccine candidate to Plasmodium falciparum. In this study, a long synthetic peptide (LSP) representing a P. vivax TRAP fragment involved in hepatocyte invasion was formulated in both Freund and Montanide ISA 720 adjutants and administered by
Memórias do Instituto Oswaldo Cruz. Publicado em: 17/05/2007
-
9. Cattle submited with vaccine stress with synthetic immunogenis challenged with Rhipicephalus (Boophilus) microplus and Babesia bovis: immunoistochemistry expression of heat shock proteins and blood biochemical / Bovinos submetidos a estresse vacinal com imunógenos sintéticos e desafiados com Rhipicephalus (Boophilus) microplus e Babesia bovis: expressão imunoistoquímica de proteínas de choque térmico (HSP70 e HSP90) e bioquímica sangüínea
The expression of HSP70 and HSP90 was evaluated through immunoistochemistry studies in bovine inoculated with synthetic peptides SBbo23290 and SBm7462 applied simultaneously, in association or in individual presentation. The animals received three applications with 30 days of interval among them and after challenged with the Babesia bovis strain UFV1 - 9th p
Publicado em: 2007
-
10. Células de doadores normais primadas in vitro respondem ao antígeno ovular solúvel e ao peptídeo sintético MAP4 derivado da triose fosfato isomerase do Schistosoma mansoni. / Cells of normal primed givers in vitro answer to the antigen to ovular soluble and synthetic peptíde MAP4 derived from triose-phosphate isomerase of the Schistosoma mansoni.
It has been well established that Schistosoma mansoni induces an initial CD4+ T-cell response. The early events in the immune response to schistosomiasis have been evaluated in mice but few studies have focused on the early response in humans, especially in regard to parasite antigens that are potential vaccine candidates. To study the early immune response
Publicado em: 2007
-
11. Expressão e purificação de uma proteína multiepítopo recombinante desenhada a partir de proteínas do vírus da hepatite C
Hepatitis C is considered one of the largest problems of public health in the world, inclusively in Brazil, whereas a preventive vaccine none is available; the number of asymptomatic infections is elevated and for control of the disease, there exist only imported kits. Considering, principally, the increase of preoccupation with the detection of precocious h
Publicado em: 2007
-
12. Antígenos compartidos entre Plasmodium falciparum y Anopheles albimanus
The presence of common antigens between Plasmodium falciparum and Anopheles albimanus was demonstrated. Different groups of rabbits were immunized with: crude extract from female An. albimanus (EAaF), red blood cells infected with Plasmodium falciparum (EPfs), and the SPf66 synthetic malaria vaccine. The rabbit's polyclonal antibodies were evaluated by ELISA
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2006-12