Survivin
Mostrando 1-12 de 58 artigos, teses e dissertações.
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1. The role of Survivin as a biomarker and potential prognostic factor for breast cancer
RESUMO O câncer de mama (CM) é um dos principais problemas de saúde em todo o mundo. Como o câncer mais comum em mulheres no mundo e no Brasil, precedido apenas pelo câncer de pele não melanoma, essa neoplasia corresponde a aproximadamente 28% dos novos casos por ano no país. O CM também afeta homens, embora a incidência corresponda a apenas 1% do t
Rev. Assoc. Med. Bras.. Publicado em: 22/07/2019
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2. Punica granatum suppresses colon cancer through downregulation of Wnt/β-Catenin in rat model
Abstract This study aims to elucidate the beneficial effect of Punica granatum L., Lythraceae (pomegranate) peel extract in the management of colon cancer induced intrarectally with N-methylnitrosourea. Adult male Sprague-Dawley rats were administered N-methylnitrosourea (2 mg in 0.5 ml water/rat) intrarectally three times/week for five weeks to induce color
Rev. bras. farmacogn.. Publicado em: 2017-10
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3. Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells
PURPOSE: To investigate the anticancer activity of ellagic acid (EA) in U251 human glioblastoma cells and its possible molecular mechanism. METHODS: The cells were treated with EA at various concentrations for different time periods. Cell viability and cell proliferation were detected by cell counting kit-8(CCK-8) assay and live/dead assay respectively. Ce
Acta Cir. Bras.. Publicado em: 2016-02
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4. Respiratory immunohistochemical study in rats exposed to cigarette smoke and alcohol
PURPOSE: To investigate the effects of exposure to cigarette and alcohol on immunohistochemical disorders caused by these attacks to respiratory system of rats.METHODS:Sixty male Wistar rats in four groups: control, cigarette smoke, alcohol and cigarette smoke + alcohol during 260 days. Immunohistochemistry was performed by researching survivin and protein P
Acta Cir. Bras.. Publicado em: 2015-03
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5. Downregulation of survivin by siRNA inhibits invasion and promotes apoptosis in neuroblastoma SH-SY5Y cells
Neuroblastoma is a solid tumor that occurs mainly in children. Malignant neuroblastomas have a poor prognosis because conventional chemotherapeutic agents are not very effective. Survivin, a member of the inhibitor of the apoptosis protein family, plays a significant role in cell division, inhibition of apoptosis, and promotion of cell proliferation and inva
Braz J Med Biol Res. Publicado em: 23/05/2014
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6. Early responses of the STAT3 pathway to platinum drugs are associated with cisplatin resistance in epithelial ovarian cancer
Cisplatin resistance remains one of the major obstacles when treating epithelial ovarian cancer. Because oxaliplatin and nedaplatin are effective against cisplatin-resistant ovarian cancer in clinical trials and signal transducer and activator of transcription 3 (STAT3) is associated with cisplatin resistance, we investigated whether overcoming cisplatin res
Braz J Med Biol Res. Publicado em: 13/08/2013
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7. Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo
OBJECTIVE: To determine whether curcumin reverses the multidrug resistance of human colon cancer cells in vitro and in vivo. METHODS: In a vincristine-resistant cell line of human colon cancer, the cell viability of curcumin-treated cells was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Rhodamine123 efflux was e
Clinics. Publicado em: 2013-05
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8. The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins
Flavonoids are products of secondary metabolism of plants. They are present in herbs and trees and also act as natural chemopreventives and anticancer agents. Ligaria cuneifolia (Ruiz & Pav.) Tiegh., Loranthaceae, is a hemiparasite species that belongs to Argentine flora. Phytochemical studies have disclosed the presence of quercetin, catechin-4β-ol and pro
Rev. bras. farmacogn.. Publicado em: 26/03/2013
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9. Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis
There is an urgent need to improve the clinical management of non-small cell lung cancer (NSCLC), one of the most frequent causes of cancer-related deaths in men and women worldwide. Rhazya stricta, an important medicinal plant used in traditional Oriental medicine, possesses anti-oxidant, anti-carcinogenic and free radical scavenging properties. This study
Genet. Mol. Biol.. Publicado em: 01/02/2013
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10. Avaliação da transfecção de células dendríticas com RNA tumoral como estratégia para indução de imunidade específica em pacientes com leucemia linfóide crônica. / Evaluation of dendritic cell transfection with tumor RNA as a strategy to induce specific immunity in chronic lymphoid leukemia patients.
O desenvolvimento da imunoterapia do câncer baseada em células dendríticas (DCs) é alvo de vários estudos. Para tumores sólidos, a abordagem baseada no uso de DCs alogenêicas fundidas com células tumorais tem se mostrado relativamente eficaz. Por outro lado, esta estratégia necessita uma massa tumoral considerável de cada paciente para a geração
Publicado em: 2010
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11. Comportamento das células epiteliais de lesões císticas odontogênicas : um estudo imunoistoquímico
O propósito do presente estudo foi analisar as células epiteliais odontogênicas procurando um entendimento maior sobre a natureza e conseqüentemente o comportamento de algumas lesões odontogênicas. A expressão imunoistoquímica de p53 e PCNA foi analisada em cisto radicular, cisto dentígero, ceratocisto odontogênico e cisto odontogênico calcificant
Publicado em: 2007
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12. Avaliação da expressão imunoistoquímica das proteínas survivina e b- catenina em queilite actínica e carcinoma epidermóide de lábio / Evaluation of the immunohistochemical expression of the survivin and b-catenin proteins in actinic cheilitis and squamous cell carcinoma of the lip
A queilite actínica é uma lesão causada pela exposição excessiva aos raios ultra-violeta (UV). Atingindo mais homens a partir da 5º década de vida e de pele clara, possuindo grande potencial de malignização, quando originará o carcinoma epidermóide de lábio, a malignidade mais comum em boca. Seu diagnóstico na maioria das vezes é tardio e quand
Publicado em: 2007