Structure Activity Relationships
Mostrando 1-12 de 361 artigos, teses e dissertações.
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1. Fantastic Lifestyle Questionnaire applied to undergraduate medical students during the COVID-19 pandemic: a factor analysis
SUMMARY OBJECTIVE: To identify what structure represents life style in medical students, in a public university, with the application of the Fantastic Lifestyle Questionnaire. METHODS: This is a cross-sectional exploratory study. The Fantastic Lifestyle Questionnaire was applied online to medical students. Factorial analysis was realized and factors were e
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Anti-Hyperglycemic Activities, Molecular Docking and Structure-Activity Relationships (SARs) Studies of Endiandric Acids and Kingianins from Endiandra kingiana
Diabetes has become a severe chronic disease worldwide with patients significantly increasing daily. Due to the side effects of insulin and oral hypoglycaemic agents employed in diabetes treatment, scientists are working hard to develop alternative approaches from natural plants that inhibit α-amylase and α-glucosidase. Consequently, by performing a phytoc
Journal of the Brazilian Chemical Society. Publicado em: 2022
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3. Design, Synthesis and Antifungal Activity of New Schiff Bases Bearing 2-Aminothiophene Derivatives Obtained by Molecular Simplification
Seventeen Schiff bases bearing 2-aminothiophene derivatives were designed and synthesized using molecular simplification. The resulting compounds (4a-4q) were evaluated for their in vitro antifungal activity against dermatophytes. Prediction of their druglikeness and pharmacokinetic properties, establishment of their structure-activity relationships (SAR), a
J. Braz. Chem. Soc.. Publicado em: 2021-05
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4. Automated Framework for Developing Predictive Machine Learning Models for Data-Driven Drug Discovery
The increasing availability of extensive collections of chemical compounds associated with experimental data provides an opportunity to build predictive quantitative structure-activity relationship (QSAR) models using machine learning (ML) algorithms. These models can promote data-driven decisions and have the potential to speed up the drug discovery process
J. Braz. Chem. Soc.. Publicado em: 2021-01
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5. Las operaciones con los sistemas de signos y su papel en el desarrollo de la psiquis infantil
Resumo Neste artigo se examinam os principais postulados da teoria histórico-cultural de L. S. Vigotski, em particular a função, a formação, a gênese e a estrutura das funções psíquicas superiores; a atividade simbólica e os meios (sistemas de signos) com que se opera. Analisam-se as relações entre desenvolvimento psíquico e ensino.Abstract In t
Psicol. Esc. Educ.. Publicado em: 09/12/2019
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6. ABSORPTIVE CAPACITY OF SIGNALS CAPTURED FROM ENVIRONMENT FOR INNOVATION
RESUMO Objetivo: Descrever a capacidade absortiva (ACAP) de empresas industriais sergipanas, do segmento de confecção têxtil, para os sinais capturados do ambiente que indicam necessidade de inovação em resposta às mudanças do mercado. As bases teóricas da capacidade absortiva postulam que a empresa que desenvolve essa capacidade possui habilidade e
RAM, Rev. Adm. Mackenzie. Publicado em: 04/11/2019
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7. Chemical diversity and activity profiles of HIV-1 reverse transcriptase inhibitors from plants
Abstract Current challenges to antiretroviral therapy have opened new vistas in the search for novel drugs from natural products. This review focusses on plants as sources of inhibitors for human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Based on a systematic search of the literature, anti-HIV-1 reverse transcriptase activity was recorded
Rev. bras. farmacogn.. Publicado em: 17/10/2019
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8. A Microwave-Enhanced Synthesis and Biological Evaluation of N-Aryl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d ]pyrimidin-4-amines
A series of N-aryl-5,6,7,8-tetra-hydrobenzo[4,5]thieno[2,3-d ]pyrimidin-4-amines were synthesized in moderate to good yield by using a microwave-enhanced conditions. The selected compounds were evaluated for their cytotoxic effects (IC50 values) on human pulmonary carcinoma (A549), murine BALB/c spontaneous colon adenocarcinoma (CT26) and human hepatocellula
J. Braz. Chem. Soc.. Publicado em: 04/07/2019
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9. Development of Web and Mobile Applications for Chemical Toxicity Prediction
Computational tools are recognized to provide high-quality predictions for the assessment of chemical toxicity. In the recent years, mobile devices have become ubiquitous, allowing for the development of innovative and useful models implemented as chemical software applications. Here, we will briefly discuss this recent uptick in the development of web-based
J. Braz. Chem. Soc.. Publicado em: 2018-05
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10. Synthesis and antimicrobial activity of new amino derivatives of pyrano[4’’,3’’:4’,5’]pyrido[3’,2’:4,5]thieno[3,2-d]pyrimidine
ABSTRACT Annulated thienopyrimidine derivatives attracted big interest of the scientific community due to their broad spectrum of biological activities among which are the inhibition of phosphodiesterase, antiproliferative and antimicrobial activities. As a continuation of our studies on the synthesis and biological activity of fused thieno[3,2-d]pyrimidine
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
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11. EQUILÍBRIO QUÍMICO E CINÉTICA ENZIMÁTICA DA INTERAÇÃO DE α-AMILASE COM COMPOSTOS FENÓLICOS ENCONTRADOS EM CERVEJA
α-amylase is a key enzyme in the production of beer due to the breakdown of starch into fermentable sugars. During the preparation of the brewing mash, the enzyme can be affected by polyphenols present in the mixture. Our aim was to evaluate the kinetics and equilibrium of the interaction of α-amylase with some polyphenols (chlorogenic, caffeic, ferulic ac
Quím. Nova. Publicado em: 2017-08
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12. A EVOLUÇÃO DA QUÍMICA MEDICINAL NO BRASIL: AVANÇOS NOS 40 ANOS DA SOCIEDADE BRASILEIRA DE QUÍMICA
Medicinal Chemistry includes the invention, discovery, design, identification, and interpretation of the molecular mechanism of action of biologically active compounds. In addition to the discovery of bioactive molecules, Medicinal Chemistry investigates drug metabolism and the relationships between chemical structure and biological activity. The advances ac
Quím. Nova. Publicado em: 2017-07