Structural Replication
Mostrando 1-12 de 1084 artigos, teses e dissertações.
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1. Effects of the management control system in unethical behaviors
Purpose This study investigates which dimensions of the management control system (MCS) increase the perception of organizational justice and reduce unethical behavior in the perception of managers. The purpose of this paper is to validate the theoretical model of the study of Langevin and Mendoza (2012), testing the theoretical hypotheses formulated by the
RAUSP Manag. J.. Publicado em: 02/05/2019
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2. Human papillomavirus and genome instability: from productive infection to cancer
Infection with high oncogenic risk human papillomavirus types is the etiological factor of cervical cancer and a major cause of other epithelial malignancies, including vulvar, vaginal, anal, penile and head and neck carcinomas. These agents affect epithelial homeostasis through the expression of specific proteins that deregulate important cellular signaling
Clinics. Publicado em: 06/09/2018
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3. Decrease in Dengue virus-2 infection and reduction of cytokine/chemokine production by Uncaria guianensis in human hepatocyte cell line Huh-7
ABSTRACT BACKGROUND Dengue fever may present hemorrhages and cavitary effusions as result of exacerbated immune responses. We investigated hydro-alcoholic extracts from leaves (UGL) and bark (UGB) of the medicinal species Uncaria guinanensis with respect to antiviral effects in Dengue virus (DENV) infection and in immunological parameters associated with i
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-06
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4. Study on the NaOH/metakaolin Ratio and Crystallization Time for Zeolite a Synthesis from Kaolin Using Statistical Design
The NaOH/metakaolin ratio and crystallization time were studied for the synthesis of zeolite NaA from a sample of kaolin from a Capim mine. The tests were carried out by using statistical design with axial points and replication of the central point. The samples obtained were characterized by X-ray diffraction (DRX), scanning electron microscopy and chemical
Mat. Res.. Publicado em: 13/04/2017
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5. The shift from low to high non-structural protein 1 expression in rotavirus-infected MA-104 cells
A hallmark of group/species A rotavirus (RVA) replication in MA-104 cells is the logarithmic increase in viral mRNAs that occurs four-12 h post-infection. Viral protein synthesis typically lags closely behind mRNA synthesis but continues after mRNA levels plateau. However, RVA non-structural protein 1 (NSP1) is present at very low levels throughout viral rep
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-06
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6. Replicating animal mitochondrial DNA
The field of mitochondrial DNA (mtDNA) replication has been experiencing incredible progress in recent years, and yet little is certain about the mechanism(s) used by animal cells to replicate this plasmid-like genome. The long-standing strand-displacement model of mammalian mtDNA replication (for which single-stranded DNA intermediates are a hallmark) has b
Genet. Mol. Biol.. Publicado em: 2013
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7. Relationships between chromatin remodeling and DNA damage repair induced by 8-methoxypsoralen and UVA in yeast Saccharomyces cerevisiae
Eukaryotic cells have developed mechanisms to prevent genomic instability, such as DNA damage detection and repair, control of cell cycle progression and cell death induction. The bifunctional compound furocumarin 8-methoxy-psoralen (8-MOP) is widely used in the treatment of various inflammatory skin diseases. In this review, we summarize recent data about t
Genet. Mol. Biol.. Publicado em: 2012
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8. Organization and variation of mitochondrial DNA control region in pleurodiran turtles
Three complete mitochondrial DNA (mtDNA) control regions (CRs) of Chelodina rugosa (Ogilby, 1890), Chelus fimbriata (Schneider, 1783), and Podocnemis unifilis (Troschel, 1848) were firstly determined using Long-PCR method and the length were 1,016 bp, 1,149 bp, and 985bp, respectively. Together with CRs of Pelomedusa subrufa (Bonnaterre, 1789) and nearly com
Zoologia (Curitiba). Publicado em: 2011-08
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9. Structural analysis of human respiratory syncytial virus P protein: identification of intrinsically disordered domains
Human Respiratory Syncytial Virus P protein plus the viral RNA, N and L viral proteins, constitute the viral replication complex. In this report we describe that HRSV P protein has putative intrinsically disordered domains predicted by in silico methods. These two domains, located at the amino and caboxi terminus, were identified by mass spectrometry analysi
Brazilian Journal of Microbiology. Publicado em: 2011-03
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10. Assessing protein stability of the dimeric DNA-binding domain of E2 human papillomavirus 18 with molecular dynamics
The objective of this study is to understand the structural flexibility and curvature of the E2 protein of human papillomavirus type 18 using molecular dynamics (6 ns). E2 is required for viral DNA replication and its disruption could be an anti-viral strategy. E2 is a dimer, with each monomer folding into a stable open-faced β-sandwich. We calculated the m
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-03
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11. NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virus
The development of novel therapeutic agents is essential for combating the increasing number of cases of dengue fever in endemic countries and among a large number of travelers from non-endemic countries. The dengue virus has three structural proteins and seven non-structural (NS) proteins. NS3 is a multifunctional protein with an N-terminal protease domain
Genetics and Molecular Biology. Publicado em: 2010
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12. The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review
The only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventional attempts to induce protective antibody and CD8+ lymphoc
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-03