Steroids Receptors
Mostrando 1-12 de 106 artigos, teses e dissertações.
-
1. Classic and current concepts in adrenal steroidogenesis: a reappraisal
ABSTRACT Adrenal steroid biosynthesis and its related pathology are constant evolving disciplines. In this paper, we review classic and current concepts of adrenal steroidogenesis, plus control mechanisms of steroid pathways, distribution of unique enzymes and cofactors, and major steroid families. We highlight the presence of a “mineralocorticoid (MC) pat
Archives of Endocrinology and Metabolism. Publicado em: 2022
-
2. Diretrizes para prevenção e tratamento da osteoporose induzida por glicocorticoide
Os glicocorticoides (GC) são prescritos por praticamente todas as especialidades médicas, e cerca de 0,5% da população geral do Reino Unido utiliza esses medicamentos. Com o aumento da sobrevida dos pacientes com doenças reumatológicas, a morbidade secundária ao uso dessa medicação representa um aspecto importante que deve ser considerado no manejo
Revista Brasileira de Reumatologia. Publicado em: 2012-08
-
3. Expressão e valor prognóstico dos receptores de estrógeno e progesterona em tumores borderline e carcinomas de ovário / Expression and prognostic value of estrogen and progesterone receptors status in borderline ovarian tumors and ovarian carcinomas
Introdução: Evidências recentes sugerem que a estimulação hormonal dos esteróides pode estar envolvida no desenvolvimento e prognóstico das neoplasias de ovário. O estrogênio é um importante regulador do crescimento e diferenciação das células ovarianas, enquanto a progesterona pode oferecer proteção contra os efeitos mutagênicos do estrógen
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
-
4. Estrogens and male reproduction: a new concept
The mammalian testis serves two main functions: production of spermatozoa and synthesis of steroids; among them estrogens are the end products obtained from the irreversible transformation of androgens by a microsomal enzymatic complex named aromatase. The aromatase is encoded by a single gene (cyp19) in humans which contains 18 exons, 9 of them being transl
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-06
-
5. Sex differences in angiotensin II- induced hypertension
Sex differences in the development of hypertension and cardiovascular disease have been described in humans and in animal models. In this paper we will review some of our studies which have as their emphasis the examination of the role of sex differences and sex steroids in modulating the central actions of angiotensin II (ANG II) via interactions with free
Brazilian Journal of Medical and Biological Research. Publicado em: 26/03/2007
-
6. REGULATION OF STEROID RECEPTORS AND FOLLICULAR DYNAMICS IN HORMONAL INDUCTION SYSTEM POSTPARTUM BEEF COWS / REGULAÇÃO DE RECEPTORES ESTERÓIDES E DINÂMICA FOLICULAR EM UM SISTEMA DE INDUÇÃO HORMONAL PÓSPARTO EM VACAS DE CORTE
The objective of the present study was to determine the action of gestagens and estradiol benzoate (EB) on the mechanism of premature regression of the first corpus luteum (CL) after parturition, and to develop an efficient artificial insemination system for suckling beef cows. The effect of pre-exposure to gestagens and EB on the expression of the alpha (ER
Publicado em: 2005
-
7. Effects of estrogen on the vascular system
The cardiovascular protective actions of estrogen are partially mediated by a direct effect on the vessel wall. Estrogen is active both on vascular smooth muscle and endothelial cells where functionally competent estrogen receptors have been identified. Estrogen administration promotes vasodilation in humans and in experimental animals, in part by stimulatin
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-09
-
8. Estudo das relações entre estrutura-atividade de progestogenios contraceptivos, atraves da utilização de parametros fisico-quimicos calculados e metodos de reconhecimento de padrão
Molecular geometries of 23 17a-acetoxyprogesterones substituted and other 11 steroids were calculated with the semi-empirical method AM1. Molecular properties were calculated using the wave functions generated by AM1 as well as other computational methods. The molecular properties can be classified as: electronic, steric and hidrophobic. These parameters wer
Publicado em: 1998
-
9. Estudo teorico das relações entre estrutura e atividade biologica : hormonios, esteroides e hidrocarbonetos policiclicos aromaticos
Using the PCILO rnethod, we studied which conformational factors were involved in the biological action of progesterone, corticosterone, cortisol and contraceptives - norethindrone, d-norgestrel, normethandrone and 17b-hidroxy-17-methylestra-4,15-dien-3-one. It was shown that the steroids in isolated state have generally similar conformations to observed one
Publicado em: 1981
-
10. Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors
Neuroactive steroids are potent modulators of γ-aminobutyric acid type A receptors (GABAARs), and their behavioral effects are generally viewed in terms of altered inhibitory synaptic transmission. Here we report that, at concentrations known to occur in vivo, neuroactive steroids specifically enhance a tonic inhibitory conductance in central neurons that i
National Academy of Sciences.
-
11. Aldosterone receptors and the evaluation of plasma mineralocorticoid activity in normal and hypertensive states.
Aldosterone receptors from rat kidney slices were utilized in a competitive binding technique to analyze the contribution of various steroids to plasma "mineralocorticoid" activity and to assess their possible role in hypertension. To consider simultaneously the plasma binding, steroids were incubated with slices in undiluted plasma; competitor activities fo
-
12. Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.
Patients with heterozygous familial hypercholesterolemia (FH) have a deficiency of receptors for plasma low-density lipoprotein (LDL) that impairs removal of LDL from plasma. In these patients, mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase [mevalonate:NAD+ oxidoreductase (CoA-acylating), EC 1.1.1.88], increases receptors for LDL and dec