Solid Phase Organic Synthesis
Mostrando 13-17 de 17 artigos, teses e dissertações.
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13. A síntese orgânica em fase sólida e seus suportes poliméricos mais empregados
In the last decade we have seen improved a powerfull tool to medicinal chemistry: the Solid Phase Organic Synthesis (SPOS). This metodology can be used to synthesize a large library of compounds in a short time by combinatorial chemistry, where simple chemical substances can be combinated one to each other building a library of complex compounds. In this wor
Química Nova. Publicado em: 2001-12
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14. Nonconventional amide bond formation catalysis: programming enzyme specificity with substrate mimetics
This article reports on the design and characteristics of substrate mimetics in protease-catalyzed reactions. Firstly, the basis of protease-catalyzed peptide synthesis and the general advantages of substrate mimetics over common acyl donor components are described. The binding behavior of these artificial substrates and the mechanism of catalysis are furthe
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-05
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15. DNA Display III. Solid-Phase Organic Synthesis on Unprotected DNA
DNA-directed synthesis represents a powerful new tool for molecular discovery. Its ultimate utility, however, hinges upon the diversity of chemical reactions that can be executed in the presence of unprotected DNA. We present a solid-phase reaction format that makes possible the use of standard organic reaction conditions and common reagents to facilitate ch
Public Library of Science.
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16. "Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.
Solid-phase chemistry, organic synthesis, and an apparatus for multiple, simultaneous synthesis have been combined to generate libraries of organic compounds ("diversomers"). Arrays of compounds were synthesized over two to three steps incorporating chemically diverse building blocks on a polystyrene-based solid support in a multiple, simultaneous manner. Th
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17. Liquid-phase combinatorial synthesis.
A concept termed liquid-phase combinatorial synthesis (LPCS) is described. The central feature of this methodology is that it combines the advantages that classic organic synthesis in solution offers with those that solid-phase synthesis can provide, through the application of a linear homogeneous polymer. To validate this concept two libraries were prepared