Slmv
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Avaliação do efeito do extrato etanólico bruto de Harpagophytum procumbens em camundongos infectados com Toxocara canis
A Síndrome da Larva Migrans Visceral (SLMV) é uma parasitose, causada pelo Toxocara canis, um dos helmintos mais freqüente em cães. Nos hospedeiros definitivos, se apresentam em diferentes formas morfológicas, ovos embrionados, adultos machos e fêmeas. Entretanto, nos hospedeiros não habituais (ex.: homem e roedores), apresentam-se apenas no estádio
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012
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2. Avaliação da expressão das moléculas CD80, CD86 e MHCII em eosinófilos durante a síndrome da larva migrans visceral
O eosinófilo é uma célula hematopoiética, originada a partir de células precursoras presentes na medula óssea, cuja diferenciação e proliferação são reguladas por citocinas como GMCSF, IL-3 e IL-5. Quando ativados, os eosinófilos são capazes de realizar fagocitose de pequenas partículas e bactérias, mas sua principal forma de atuação no proc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
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3. Sorting to Synaptic-like Microvesicles from Early and Late Endosomes Requires Overlapping but Not Identical Targeting Signals
In PC12 neuroendocrine cells, synaptic-like microvesicles (SLMV) are thought to be formed by two pathways. One pathway sorts the proteins to SLMV directly from the plasma membrane (or a specialized domain thereof) in an adaptor protein complex 2-dependent, brefeldin A (BFA)-insensitive manner. Another pathway operates via an endosomal intermediate, invo
The American Society for Cell Biology.
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4. Di-Leucine Signals Mediate Targeting of Tyrosinase and Synaptotagmin to Synaptic-like Microvesicles within PC12 Cells
One pathway in forming synaptic-like microvesicles (SLMV) involves direct budding from the plasma membrane, requires adaptor protein 2 (AP2) and is brefeldin A (BFA) resistant. A second route leads from the plasma membrane to an endosomal intermediate from which SLMV bud in a BFA-sensitive, AP3-dependent manner. Because AP3 has been shown to bind to a di-leu
The American Society for Cell Biology.
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5. Synaptic Vesicles Form by Budding from Tubular Extensions of Sorting Endosomes in PC12 Cells
The putative role of sorting early endosomes (EEs) in synaptic-like microvesicle (SLMV) formation in the neuroendocrine PC12 cell line was investigated by quantitative immunoelectron microscopy. By BSA-gold internalization kinetics, four distinct endosomal subcompartments were distinguished: primary endocytic vesicles, EEs, late endosomes, and lysosomes. As
The American Society for Cell Biology.
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6. The Zinc Transporter ZnT3 Interacts with AP-3 and It Is Preferentially Targeted to a Distinct Synaptic Vesicle Subpopulation
Synaptic vesicles (SV) are generated by two different mechanisms, one AP-2 dependent and one AP-3 dependent. It has been uncertain, however, whether these mechanisms generate SV that differ in molecular composition. We explored this hypothesis by analyzing the targeting of ZnT3 and synaptophysin both to PC12 synaptic-like microvesicles (SLMV) as well as SV i
The American Society for Cell Biology.
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7. Secretagogue-triggered Transfer of Membrane Proteins from Neuroendocrine Secretory Granules to Synaptic-like Microvesicles
The membrane proteins of all regulated secretory organelles (RSOs) recycle after exocytosis. However, the recycling of those membrane proteins that are targeted to both dense core granules (DCGs) and synaptic-like microvesicles (SLMVs) has not been addressed. Since neuroendocrine cells contain both RSOs, and the recycling routes that lead to either organelle
The American Society for Cell Biology.