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Mostrando 1-12 de 2451 artigos, teses e dissertações.
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1. Engineered scPDL1-DM1 drug conjugate with improved in vitro analysis to target PD-L1 positive cancer cells and intracellular trafficking studies in cancer therapy
Abstract Antibody-drug conjugates (ADC), precisely deliver a cytotoxic agent to antigen-expressing tumor cells by using specific binding strategies of antibodies. The ADC has shown the ability of potent bio-therapeutics development but indefinite stoichiometric linkage and full-length antibody penetration compromised the field of its advancement. Single chai
Genet. Mol. Biol.. Publicado em: 17/01/2020
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2. Compared activity of agonist molecules towards ecdysone receptor in insect cell-based screening system
RESUMO: O receptor de ecdisona, naturalmente ativado por hormônios esteroidais, é uma proteína-chave nos processos de muda e reprodução de insetos. A ativação artificial desse receptor por meio de pesticidas específicos induz um processo de ecdise anômala, levando o inseto à morte por dessecação e inanição. Neste trabalho, foi estabelecido um p
Arq. Inst. Biol.. Publicado em: 25/11/2019
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3. Characterization of people with hemato-oncological diseases admitted to an emergency unit
Resumo Objetivos: Identificar o perfil demográfico, clínico e os motivos de busca de atendimento de pessoas com doenças hemato-oncológicas atendidas em uma unidade de urgência e emergência. Métodos: Trata-se de um estudo quantitativo correlacional, descritivo, realizado na unidade de urgência e emergência de um hospital geral do interior do Rio Gr
Esc. Anna Nery. Publicado em: 18/07/2019
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4. Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review
Resumo Objetivo: a aplicação da força ortodôntica libera múltiplas enzimas no fluído crevicular gengival (FCG), desencadeando a ativação, reabsorção, reversão, deposição de elementos ósseos e degradação da matriz extracelular. A presente revisão sistemática avaliou criticamente toda a evidência disponível sobre os níveis de enzimas dura
Dental Press J. Orthod.. Publicado em: 20/05/2019
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5. Evaluation of the diagnostic potential of CD1a immunohistochemistry for visceral leishmaniasis
ABSTRACT Visceral Leishmaniasis is a public health problem caused by protozoans of the genus Leishmania. K39 serological test is commonly used in the initial investigation, with high specificity, but variable sensitivity. Amastigotes can be identified by optical microscopy, however, the differential diagnosis with cellular debris or other intracellular paras
Rev. Inst. Med. trop. S. Paulo. Publicado em: 18/04/2019
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6. Formulation development and evaluation of colon targeted delayed release methotrexate pellets for the treatment of colonic carcinoma
Colonic carcinoma is one of the most common internal malignancies and is the second leading cause of deaths in United States. Methotrexate (MTX) is a drug of choice in the treatment of colon cancer. The aim of the present research work was to develop and characterize colon targeted pellets of MTX for treatment of colonic carcinoma. The product and process pa
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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7. Evaluation of a new brand of immunochromatographic test for visceral leishmaniasis in Brazil made available from 2018
ABSTRACT Immunochromatographic tests based on the recombinant antigen K39 represent a major advance in diagnosing visceral leishmaniasis (VL) in recent years. Some performance variations are expected and have occurred in the use of several commercial rapid tests, especially in different geographical settings. This is the first evaluation in the Americas of t
Rev. Inst. Med. trop. S. Paulo. Publicado em: 13/09/2018
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8. The Accuracy of Digital Radiography for Diagnosis of Fishbone Foreign Bodies in the Throat
Abstract Introduction Some patients with a fishbone as a foreign body of difficult diagnosis may require further investigations. Generally, radiography is used as the first choice for finding the fishbone. Objective The objective of this study is to determine the accuracy of digital radiography for diagnosis of fishbone foreign body in the throat Method
Int. Arch. Otorhinolaryngol.. Publicado em: 2017-09
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9. Molecular Characterization of a MYB Protein from Oryza sativa for its Role in Abiotic Stress Tolerance
ABSTRACT The MYB family represents one of the most abundant classes of transcriptional regulators that perform pivotal role under different developmental processes and abiotic stresses. In present study, a MYB gene from Oryza sativa was selected for functional characterization. Bioinformatics analysis revealed that OsMYB1 cDNA encodes R2-R3 type DNA binding
Braz. arch. biol. technol.. Publicado em: 22/06/2017
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10. Standardization and validation of Dot-ELISA assay for Paracoccidioides brasiliensis antibody detection
Abstract Background Paracoccidioidomycosis (PCM) is a neglected systemic mycosis caused by a dimorphic fungus of the Paracoccidioides genus. The standard diagnosis is based on isolation of the fungi in culture, and by microscopic visualization of characteristic multiple budding yeast cells in biological samples. However, in some situations, access to the s
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 16/03/2017
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11. Rapid on-site cytopathological examination (ROSE) performed by endosonagraphers and its improvement in the diagnosis of pancreatic solid lesions
PURPOSE: To evaluate the diagnosis improvement of EUS-FNA when using ROSE performed by the endosonographer. METHODS: A retrospective study was conducted. A total of 48 pancreatic solid masses EUS-FNA were divided into two groups according to the availability of on-site cytology (ROSE) - the first 24 patients (group A-without ROSE) and the latter 24 cases (g
Acta Cir. Bras.. Publicado em: 2015-07
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12. Rapid tests for the detection of the Mycobacterium abscessus subsp. bolletii strain responsible for an epidemic of surgical-site infections in Brazil
A single strain of Mycobacterium abscessus subsp. bolletii, characterised by a particular rpoB sequevar and two highly related pulsed field gel electrophoresis patterns has been responsible for a nationwide outbreak of surgical infections in Brazil since 2004. In this study, we developed molecular tests based on polymerase chain reaction restriction-enzyme a
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12