Single Nucleotide Polymorphism
Mostrando 25-36 de 563 artigos, teses e dissertações.
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25. Phylogenomic and single nucleotide polymorphism analyses revealed the hybrid origin of Spondias bahiensis (family Anacardiaceae): de novo genome sequencing and comparative genomics
Abstract The genus Spondias (family Anacardiaceae) comprises 19 taxa, ten of which occur in Neotropical regions. Spondias bahiensis has been suggested to be a hybrid, although initial evidence does not support this hypothesis. The aim of this study was to test the hypothesis of the hybrid origin of S. bahiensis using high-throughput sequencing with single nu
Genet. Mol. Biol.. Publicado em: 29/11/2018
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26. Acurácia de predição genômica em feijoeiro-comum via modelos Bayesianos
RESUMO: Objetivou-se incorporar informações genômicas de marcadores SNP (“single nucleotide polymorphism”) na avaliação genética das características “stay-green” (SG), arquitetura de planta (AP), aspecto de grãos (AG) e produtividade de grãos (PG) em feijoeiro-comum via modelos Bayesianos. Estes modelos foram comparados quanto a acurácia de
Cienc. Rural. Publicado em: 06/08/2018
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27. Development of a comprehensive noninvasive prenatal test
Abstract Our aim was to develop and apply a comprehensive noninvasive prenatal test (NIPT) by using high-coverage targeted next-generation sequencing to estimate fetal fraction, determine fetal sex, and detect trisomy and monogenic disease without parental genotype information. We analyzed 45 pregnancies, 40 mock samples, and eight mother-child pairs to gene
Genet. Mol. Biol.. Publicado em: 16/07/2018
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28. Polimorfismos associados ao risco cardiovascular em indivíduos em hemodiálise: uma revisão sistemática
RESUMO A doença cardiovascular (DCV) é uma das principais causas de mortalidade de indivíduos em hemodiálise (HD). Além dos fatores de risco tradicionais, que são frequentes nesses indivíduos, também estão envolvidos fatores genéticos, com destaque para os polimorfismos de nucleotídeo único (do inglês, single nucleotide polymorphism, SNP). O pre
J. Bras. Nefrol.. Publicado em: 18/06/2018
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29. Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
Abstract The fat mass- and obesity-associated gene (FTO) is significantly associated with obesity, but the associations of FTO with obesity-related traits are not fully described. We aimed to investigate the association of the FTO single nucleotide polymorphism (SNP) rs6499640 with lipid levels in Chinese children. A total of 3503 children aged 6-18 years we
Genet. Mol. Biol.. Publicado em: 04/06/2018
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30. Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involv
Braz J Med Biol Res. Publicado em: 28/05/2018
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31. Heterozygous HTRA1 missense mutation in CADASIL-like family disease
The aim of this study was to find related pathogenic genes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in (CADASIL)-like patients. The direct sequencing and high-throughput multiplex polymerase chain reaction (PCR) was performed to screen for related genes. The clinical and imaging data of a CADASIL-like pati
Braz J Med Biol Res. Publicado em: 15/03/2018
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32. Association of single nucleotide polymorphisms in AXIN2, BMP4, and IRF6 with Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population
Abstract Non-syndromic cleft lip with or without palate (NSCL/P) is a common congenital malformation worldwide, with complex etiology. It has been proposed that interaction of genes and environmental factors play a role in the predisposition to this disease. Objectives: The aim of this study was to examine the association between AXIN2 (axis inhibition prot
J. Appl. Oral Sci.. Publicado em: 2017-12
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33. Adiponectin promoter polymorphisms are predictors of lipid profile improvement after bariatric surgery
Abstract Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5′ regions of leptin (LEP, -2548 G > A, rs7799039), resistin (RETN, -420 C > G, rs1862513) and adiponectin (ADIPOQ, -11391 G > A, rs17300539 and -11377 C > G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric s
Genet. Mol. Biol.. Publicado em: 23/10/2017
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34. Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations
Abstract Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors. In this study, we investigated whether SNPs in HPSE were a risk factor for hepatocellular carcinoma (HCC) by undertaking a comprehensive haplotype-tagging, c
Genet. Mol. Biol.. Publicado em: 02/10/2017
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35. Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis
Resumo Atualmente as investigações têm focado na identificação de Polimorfismos de Núcleo Único (SNP) envolvidos na resposta do hospedeiro e sua capacidade de gerar uma deficiência de imunidade. O objetivo deste estudo foi realizar uma revisão sistemática (RS) e uma meta-análise para avaliar a associação entre o polimorfismo do gene TNF-α (-308
Braz. Dent. J.. Publicado em: 2017-09
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36. Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis
This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polym
Braz J Med Biol Res. Publicado em: 31/08/2017