Selective Cox 2
Mostrando 1-12 de 108 artigos, teses e dissertações.
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1. Synthesis, Characterization and in vitro, in vivo and in silico Anti-Inflammatory Studies of the Novel Hybrid Based on Ibuprofen and 3-Hydroxy-Copalic Acid Isolated from Copaiba Oil (Copaifera multijuga)
A novel anti-inflammatory hybrid 3-ibuprofenyl-copalic acid (3-IbuCA) was synthesized from 3-hydroxy-copalic acid isolated from Amazonian copaiba oil (Copaifera multijuga Hayne), and the anti-inflammatory ibuprofen. After full characterization, several assays to verify its anti-inflammatory effects were performed in vitro, in vivo and in silico (molecular do
J. Braz. Chem. Soc.. Publicado em: 2020-07
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2. In Silico Target Identification and Validation for Antioxidant and Anti-inflammatory Activity of Selective Phytochemicals.
Abstract Phytochemicals present in plant extract include a number of biological active compounds which have shown promising antioxidant and anti-inflammatory activities in many animal studies. Present knowledge about the biochemical interactions of these compounds present in phytochemical extracts and target enzymes or proteins responsible for antioxidant an
Braz. arch. biol. technol.. Publicado em: 20/12/2019
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3. Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage
Abstract Objectives: Infection, inflammation and bone resorption are closely related events in apical periodontitis development. Therefore, we sought to investigate the role of cyclooxygenase (COX) in osteoclastogenesis and bone metabolism signaling in periapical bone tissue after bacterial lipopolysaccharide (LPS) inoculation into root canals. Methodology
J. Appl. Oral Sci.. Publicado em: 03/06/2019
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4. Effects of Selective Versus Non-Selective COX-2 Inhibition on Experimental Periodontitis
Resumo No presente estudo nós comparamos os efeitos de um inibidor seletivo da COX-2 (etoricoxibe) com um anti-inflamatório não esteroidal não seletivo (AINE) (diclofenaco de potássio) no processo inflamatório e perda óssea alveolar em modelo de periodontite experimental. Noventa ratos Holtzman machos (250 g) foram randomizados em quatro grupos experi
Braz. Dent. J.. Publicado em: 04/04/2019
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5. Hepatoprotective Role of α-Lipoic acid and Thymoquinone in Acetaminophen- Induced Liver Injury: Down-Regulation of COX-2 and flt-1 Expression
ABSTRACT Acetaminophen (APAP) is a widely-used analgesic, while toxic doses of which induce liver injury. Inducible cyclooxygenase-2 (COX-2) is derived prostaglandins which play an anti-inflammatory role in acetaminophen-induced hepatotoxicity. Selective activation of vascular endothelial growth factor (VEGFR1, flt -1) on endothelial cells increased mRNA lev
Braz. arch. biol. technol.. Publicado em: 17/08/2017
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6. Selective COX-2 Inhibitor (Meloxicam) and Tooth-Supporting Bone Quality. A Histomorphometric Study in Rats
Resumo Os efeitos dos fármacos anti-inflamatórios não esteroidais (AINEs) sobre a quantidade e qualidade óssea tem sido investigados ao longo dos anos.Entretanto, há falta de informação sobre o impacto dos AINEs na qualidade do osso alveolar de suporte na ausência de inflamação periodontal. Assim, o objetivo deste estudo foi avaliar, histometricame
Braz. Dent. J.. Publicado em: 2017-04
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7. Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy
Abstract The consumption of low-dose aspirin (LDA) to prevent cardiovascular disease continues to increase worldwide. Consequently, the number of chronic LDA users seeking dental procedures that require complementary acute anti-inflammatory medication has also grown. Considering the lack of literature evaluating this interaction, we analyzed the gastric and
Braz. oral res.. Publicado em: 28/11/2016
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8. Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice
People who suffer from traumatic brain injury (TBI) often experience cognitive deficits in spatial reference and working memory. The possible roles of cyclooxygenase-1 (COX-1) in learning and memory impairment in mice with TBI are far from well known. Adult mice subjected to TBI were treated with the COX-1 selective inhibitor SC560. Performance in the open f
Braz J Med Biol Res. Publicado em: 16/09/2014
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9. Cellular and molecular studies of the effects of a selective COX-2 inhibitor celecoxib in the cardiac cell line H9c2 and their correlation with death mechanisms
Cardiovascular disease is one of the leading causes of death worldwide, and evidence indicates a correlation between the inflammatory process and cardiac dysfunction. Selective inhibitors of cyclooxygenase-2 (COX-2) enzyme are not recommended for long-term use because of potentially severe side effects to the heart. Considering this and the frequent prescrib
Braz J Med Biol Res. Publicado em: 29/11/2013
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10. Ciclooxigenase-2 modula in vivo a expressão de marcadores da osteoclastogênese e genes envolvidos no metabolismo ósseo em resposta ao lipopolissacarídeo bacteriano / Ciclooxygenase-2 modulates in vivo the expression of osteoclastiogenesis makers and genes involved in bone metabolism in response to bacterial lipopolysaccharide
During an inflammatory response, several mediators are locally released in order to stimulate cellular and humoral immune response. Through the action of cyclooxygenase and lipoxygenase enzymes structural changes occur in the arachidonic acid chain leading to synthesis of prostaglandins or leukotrienes and lipoxins, respectively. Such mediators are responsib
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/06/2012
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11. Bases moleculares da ação anti-inflamatória dos ácidos oleanólico e ursólico sobre as isoformas da ciclo-oxigenase por docking e dinâmica molecular
The triterpenoids oleanolic (OA) and ursolic (UA) acids show non-selective antiinflamatory activity in vitro for cyclooxygenase (COX) isoforms. 3D conformations of OA and UA, with three possible orientations (1, 1' and 2) in the active site of isoforms COX, obtained by docking, were submitted to molecular dynamics. The results show that orientation 2 of the
Química Nova. Publicado em: 2012
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12. Study of angiogenesis and temporal expression of VEGF and its receptors VEGFR-1/Flt-1 VEGFR-2/Flk-1 during the normal alveolar bone repair and with therapeutic use of a nonsteroidal anti-inflammatory selective for COX-2 in rats / Estudo da angiogênese e da expressão temporal do VEGF e dos seus receptores VEGFR-1/Flt-1 e VEGFR-2/Flk-1 durante o reparo ósseo alveolar normal e com uso terapêutico de um antiinflamatório não esteroidal seletivo para COX-2 em ratos
Objetivo: Avaliar o efeito do Meloxicam sobre a expressão do VEGF e de seus receptores durante o reparo alveolar pós-exodontia em ratos. Material e Método: Foi realizada a exodontia do incisivo superior direito em 180 ratos Wistar, machos, com 60 dias de idade, subdivididos em dois grupos: 1) Grupo controle (n=90): os animais receberam injeção intraperi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/12/2011