Schizophrenia Etiology
Mostrando 1-12 de 21 artigos, teses e dissertações.
-
1. The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data
Objective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (a
Rev. Bras. Psiquiatr.. Publicado em: 12/01/2017
-
2. Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review
Prenatal immune challenge (PIC) in pregnant rodents produces offspring with abnormalities in behavior, histology, and gene expression that are reminiscent of schizophrenia and autism. Based on this, the goal of this article was to review the main contributions of PIC models, especially the one using the viral-mimetic particle polyriboinosinic-polyribocytidyl
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
-
3. Esquizofrenia e síndrome da deleção 22q11.2: Caracterização de genes relevantes. / Schizophrenia; deletion syndrome; genes
Background: Schizophrenia is a severe, persistent, debilitating and poorly understood psychiatric disorder. It is a complex disease with heterogeneous fenotype. Among the genetic factors that might have a role in schizophrenia, it is included 22q11.2 deletion. Objectives: We aimed to investigate chromosomal abnormalities, UFD1L and ZDHHC8 polymorphisms, TBX1
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
-
4. Neurodevelopmental risk factors in schizophrenia
The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they
Publicado em: 2010
-
5. "Efeitos da atividade da fosfolipase A2 nos receptores dopaminérgicos: implicações para a esquizofrenia" / Effects of phospholipase A2 on dopamine receptors : implications to schizophrenia
Um aumento da atividade da PLA2 e alterações do sistema dopaminérgico tem sido descrito em esquizofrenia. No presente estudo, foram investigados os efeitos da atividade da PLA2 sobre os receptores D1 e D2 em cérebro post mortem de 10 sujeitos. Foi encontrado que a PLA2GVI é responsável por 85% do total de atividade da PLA2 no cérebro. A estimulação
Publicado em: 2005
-
6. Dopaminergic profile of new heterocyclic N-phenylpiperazine derivatives
Dopamine constitutes about 80% of the content of central catecholamines and has a crucial role in the etiology of several neuropsychiatric disorders, including Parkinson's disease, depression and schizophrenia. Several dopaminergic drugs are used to treat these pathologies, but many problems are attributed to these therapies. Within this context, the search
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
-
7. Neurodevelopmental risk factors in schizophrenia
The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-02
-
8. Estudo comparativo do fluxo sanguineo cerebral regional (SPECT) entre pacientes esquizofrenicos e controle normais
The schizophrenia is a serious psychotic disturbance. It attacks preferably the young adults, causing injuries that extends to the individual s all life. It is of multifactorial etiology with genetics, environrnental and neurobiological aspects implied in its genesis. The neuroimaging studies have showed changes in the metabolism and in the regional cerebral
Publicado em: 1998
-
9. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit
Schizophrenia is a severe psychiatric disorder characterized by a complex mode of inheritance. Forebrain-specific CNB knockout mice display a spectrum of behavioral abnormalities related to altered behaviors observed in schizophrenia patients. To examine whether calcineurin dysfunction is involved in schizophrenia etiology, we undertook studies of an ini
National Academy of Sciences.
-
10. Three independent lines of evidence suggest retinoids as causal to schizophrenia
Retinoid dysregulation may be an important factor in the etiology of schizophrenia. This hypothesis is supported by three independent lines of evidence that triangulate on retinoid involvement in schizophrenia: (i) congenital anomalies similar to those caused by retinoid dysfunction are found in schizophrenics and their relatives; (ii) those loci that h
The National Academy of Sciences.
-
11. The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations
Association studies, as well as the initial translocation family study, identified the gene Disrupted-In-Schizophrenia-1 (DISC1) as a risk factor for schizophrenia. DISC1 encodes a multifunctional scaffold protein involved in neurodevelopmental processes implicated in the etiology of schizophrenia. The present study explores the contribution of the DISC locu
Oxford University Press.
-
12. Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia
Schizophrenia is a serious brain disease of uncertain etiology. A role for retroviruses in the etiopathogenesis of some cases of schizophrenia has been postulated on the basis of clinical and epidemiological observations. We found sequences homologous to retroviral pol genes in the cell-free cerebrospinal fluids (CSFs) of 10 of 35 (29%) individuals with
The National Academy of Sciences.