Rirc
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Cultura colaborativa e gestão do conhecimento em esporte e lazer
A partir da experiência de desenvolvimento e administração do RIRC, um projeto realizado pelo LaboMídia/UFSC com o apoio da Rede CEDES/Ministério do Esporte, delimitamos o uso desse repositório digital como objeto de pesquisa de uma dissertação de mestrado. Dessa forma, organizamos esse trabalho com base nas discussões teóricas que envolvem a gest�
Motriz: rev. educ. fis.. Publicado em: 2013-06
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2. Induction of Viral Interference: Effects of Poly rI·rC and Diethylaminoethyl-Dextran on the Activity of the Antiviral Protein
The activity of the antiviral protein induced by various ratios of poly rI·rC and diethylaminoethyl (DEAE)-dextran was studied. It was found that, when large doses of poly rI·rC were used, very little viral interference was observed. This effect was initially attributed to the cells being refractory for production of antiviral protein. Subsequent experimen
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3. Effectiveness of Therapy with a Multistranded Synthetic Polynucleotide Complex Against a Murine Sarcoma Virus
A known interferon stimulator, polyriboinosinic acid:polyribocytidylic acid (rI:rC), was shown to have a protective effect against a highly tumorigenic variant of the murine sarcoma virus (Moloney) designated as (MSV-PV). Mice treated intraperitoneally with different regimens of rI:rC survived significantly longer than untreated controls. The treatment was e
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4. The messenger RNA sequences in human fibroblast cells induced with poly rI.rC to produce interferon.
Induction of human fibroblast cells with poly rI.rC induces interferon mRNA which can be translated into interferon precursor in wheat germ cell free system or in Xenopus oocytes into biologically active interferon. The extent of gene expression in the poly rI.rC induced cells was compared to that of the uninduced cells by hybridization of the mRNA to comple
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5. The respective roles of the protein kinase and pppA2' p5' A2' p5 A-activated endonuclease in the inhibition of protein synthesis by double stranded RNA in rabbit reticulocyte lysates.
Double-stranded RNA (dsRNA) inhibits protein synthesis in rabbit reticulocyte lysates by activating the synthesis of the endonuclease effector pppA2' p5' A2' p5' A(2-5A) and a protein kinase which phosphorylates the protein synthesis initiation factor eIF-2. Under certain assay conditions, high concentrations of dsRNA are without inhibitory effect in many ly
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6. THE SPECIFICITY OF INTERFERON INDUCTION IN CHICK EMBRYO CELLS BY HELICAL RNA*
Treatment of chick embryo cells growing in culture with rI:rC and many other RNA-like polymers results in the induction of interferon. DEAE dextran is required to facilitate the uptake of the RNA into the cells. Interferon-inducing activity is found with a variety of double-stranded helical polynucleotides, provided that all the sugar residues are ribose. Ho
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7. Comparative Production of Interferon by Human Fetal, Neonatal, and Maternal Cells
Production of interferon was studied in fibroblasts cultured from human fetal, neonatal, and maternal tissue. Human fetal and maternal cells were paired to diminish genetic variability. Fetal cells displayed an increased response to two inducers of interferon, virus and synthetic double-stranded ribopolynucleotide. Fetal cells released 300-fold more interfer
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8. Pyran and Polyribonucleotides: Differences in Biological Activities
Maleic anhydride-divinyl ether copolymer (pyran) and the polyribonucleotides are both large polyanions with potent antiviral activity. However, they are biologically quite different. Interferon levels of 100 units or more/ml were associated with antiviral activity of polyribonucleotides. Interferon induction by pyran compounds was not primarily involved in a