Reverse Cholesterol Transport
Mostrando 1-12 de 53 artigos, teses e dissertações.
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1. Albumina modificada por glicação avançada sensibiliza macrófagos à inflamação prejudicando o transporte reverso de colesterol e a atividade anti-inflamatória da HDL / Advanced glycated albumin primes macrophages to an inflammatory response that reduces reverse cholesterol transport and impairs the HDL anti-inflammatory properties
No diabete melito, produtos de glicação avançada (AGE) reduzem o efluxo de colesterol celular o que agrava o desenvolvimento da aterosclerose. Neste estudo, investigou-se o papel da albumina modificada por glicação avançada (albumina-AGE) sobre a sensibilização de macrófagos à resposta inflamatória e o impacto da secreção de citocinas, quimocina
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/07/2012
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2. Efeito de hipolipemiantes sobre a expressão de genes envolvidos no transporte reverso do colesterol / Statin effects on expression of genes involved in reverse cholesterol transport
The efficacy of statins in reducing the risk of coronary events is not completely explained by their effects in decreasing cholesterol low-density lipoprotein (LDL-C). One of their additional effects may result from the change in concentration of high-density lipoprotein (HDL), recognized as atheroprotective, mainly for the role in reverse cholesterol transp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/09/2011
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3. Modificações oxidativas de lipoproteínas de baixa densidade e seus anticorpos : associação com componentes do transporte reverso de colesterol e com a aterosclerose carotídea em adultos sem doença aterosclerótica estabelecida / Oxidative modification of plasma low density lipoproteins and their antibodies : association with the reverse cholesterol transport and carotid atherosclerosis in adults without established aterosclerotic disease
Cardiovascular disease (DCV) is the most common cause of death on western societies, affecting both sexes, with atherosclerosis being the most important underlying pathology. Atherosclerosis is accepted worldwide as an immuneinflammatory disease, in which the participation of the immune system is crucial for the beginning of endothelial dysfunction, fatty st
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/05/2011
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4. Albumina modificada por glicação avançada no diabete melito tipo 1 e 2 prejudica o transporte reverso de colesterol e favorece o acúmulo de lípides em macrófagos / Impairment in reverse cholesterol transport and macrophage lipid accumulation induced by advanced glycated albumin drawn from uncontrolled type 1 and type 2 diabetes mellitus patients
Advanced glycation end products are prevalent in diabetes mellitus and alter lipids and lipoprotein metabolism. In this study we analyzed the role of albumin, isolated from control individuals (C, n = 12) and uncontrolled type 1 (DM 1, n = 13) and type 2 (DM 2, n = 11) diabetes mellitus patients on macrophage cholesterol removal, intracellular lipid accumula
Publicado em: 2011
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5. Efeitos do polimorfismo T-786C do gene da óxido nítrico sintase endotelial (eNOS) e/ou da atorvastatina sobre parâmetros do metabolismo lipídico em adultos assintmáticos / Effects of the polymorphism T-786C of endothelial nitric oxide synthase (eNOS) gene and/or atorvastatin on parameters of lipid metabolism in asymptomatic adults
Nitric oxide (NO) is produced in the vascular endothelium by endothelial nitric oxide synthase (eNOS), an enzyme negatively regulated by the presence of the T-786C polymorphism, leading to endothelial dysfunction. High-density lipoproteins (HDL) have well-established anti-atherogenic functions, for example mechanisms that enhance eNOS activity. Statins are d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/08/2010
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6. O treinamento físico aeróbico acelera o transporte reverso de colesterol de macrófagos em camundongos selvagens e transgênicos para CETP humana / Aerobic exercise training improves the macrophage reverse cholesterol transport in wild-type and in CETP transgenic mice
Regular exercise prevents the development of atherosclerosis. We analyzed the role of a six-week aerobic exercise training program in the macrophage reverse cholesterol transport in wild-type (WT) and in human CETP transgenic (CETP-tg) mice. Animals were randomly assigned to sedentary and trained groups (treadmill 15 m/min, 30-min sessions, 5 sessions per we
Publicado em: 2010
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7. Transferência "in vitro" de lípides de uma nanoemulsão artificial para a fração HDL de pacientes com diabetes mellitus tipo 2 / Lipid transfer "in vitro" from an artificial nanoemulsion to the HDL fraction in patients with type 2 diabetes.
Type II diabetes mellitus has become one of the worlds main public health issues. High triglyceride concentrations and low HDL-C concentrations are the main in the plasma lipids found in DM2. Hipertriglyceridemia is but one of the factors that cause lipoprotein composition, which in turn can cause alterations in particle function. The antiatherogenic effect
Publicado em: 2008
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8. Lipemia postrandial in the alterations of the activities in the cholesterol ester transfer protein or hepatic lipase in human and rodents / Lipemia pos-prandial nas alterações das atividades da proteina de tranferencia de esteres de colesterol ou da lipase hepatica em humanos e em roedores
The postprandial response to a fat overload presents proatherogenic direct effects with remanescent lipoproteins deposition in arterial walls and indirect on the triglycerides-rich lipoprotein metabolism. Alterations during the postprandial lipemia are related with the activities of cholesteryl ester transfer protein and hepatic lipase. These two proteins po
Publicado em: 2007
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9. Atherosclerosis in aged mice over-expressing the reverse cholesterol transport genes
We determined whether over-expression of one of the three genes involved in reverse cholesterol transport, apolipoprotein (apo) AI, lecithin-cholesterol acyl transferase (LCAT) and cholesteryl ester transfer protein (CETP), or of their combinations influenced the development of diet-induced atherosclerosis. Eight genotypic groups of mice were studied (AI, LC
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-03
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10. Estudo da relação entre a expressão da proteina de transferencia de colesteril ester, diabetes e aterosclerose em camundongos transgenicos
Cholesteryl ester transfer protein (CETP) mediates cholesteryl ester and triglyceride redistribution among plasma lipoproteins. Contrasting effects of variations in CETP expression and presence of diabetes on the extension of atherosclerosis have been reported in distinct animal models and metabolic contexts. The CETP expression was studied in streptozotocin
Publicado em: 2003
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11. Metabolismo de lipoproteinas plasmaticas em tabagistas : proteinas reguladoras e modificações quimicas das lipoproteinas de baixa densidade
A aterosclerose é uma doença imuno-inflamatória e de caráter multifatorial. O tabagismo é um de seus principais fatores de risco, existindo grande controvérsia na literatura quanto aos mecanismos fisiopatológicos de sua aterogenicidade. Avaliamos os efeitos metabólicos e oxidantes do fumo em urna população sadia adulta, composta de fumantes crônic
Publicado em: 2002
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12. Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo
Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers its cholesterol to the liver facilitating excretion. Most HDL in plasma is cholesterol-rich. We demonstrate that treating plasma
American Society for Biochemistry and Molecular Biology.