Reticulimunodeficiencia Comum Variavelo Endoplasmatico
Mostrando 1-1 de 1 artigos, teses e dissertações.
-
1. Dysregulation of unfolded protein response associated with common variable immunodeficiency. / A desregulação da via UPR associada à imunodeficiência comum variável.
Common Variable Immunodeficiency (CVID) is characterized by hypogammaglobulinemia and recurrent infections. Herein we addressed the role of Unfolded Protein Response (UPR) in the pathogenesis of the disease. Augmented unspliced XBP-1 mRNA concurrent with co-localization of IgM and BiP was found in one CVID patient. Sequencing of RT-PCR amplicons did not reve
Publicado em: 2007