Responses Humoral And Cellular
Mostrando 1-12 de 393 artigos, teses e dissertações.
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1. Enhancing immune effects of a DNA vaccine against kidney cancer using CD40L as an adjuvant
The use of specific combinations of antigens and adjuvant represents a promising approach for increasing the immunogenicity of DNA vaccines. In the present study, we evaluated the immunity and antitumor effects of DNA vaccines with G250 as the target antigen in a mouse model of renal cell carcinoma. We constructed two recombinant plasmids, pVAX1-G250 and pVA
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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2. Melanoma: tumor microenvironment and new treatments
Abstract: In the recent past years, many discoveries in the tumor microenvironment have led to changes in the management of melanoma and it is rising up hopes, specially, to those in advanced stages. FDA approved seven new drugs from 2011 to 2014. They are: Vemurafenib, Dabrafenib and Trametinib, kinases inhibitors used for patients that have BRAFV600E mutat
An. Bras. Dermatol.. Publicado em: 2017-03
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3. The immunogenicity and anti-tumor effects of a lung cancer DNA vaccine harboring a MUC-1 and GM-CSF fusion gene
ABSTRACT DNA vaccines have been shown to be an effective approach to induce antigen-specific cellular and humoral immunity. However, the inability of DNA vaccines to elicit strong immune responses in clinical trials limits the application of DNA vaccines. Here, we developed a new DNA vaccine based on MUC1, which has been suggested as a potential target for l
Braz. arch. biol. technol.. Publicado em: 27/06/2016
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4. The mc2-CMX vaccine induces an enhanced immune response against Mycobacterium tuberculosis compared to Bacillus Calmette-Guérin but with similar lung inflammatory effects
Although the attenuated Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine has been used since 1921, tuberculosis (TB) control still proceeds at a slow pace. The main reason is the variable efficacy of BCG protection against TB among adults, which ranges from 0-80%. Subsequently, the mc2-CMX vaccine was developed with promising results. Nonetheless,
Mem. Inst. Oswaldo Cruz. Publicado em: 2016-04
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5. Immunological response to re-infections with clones of the Colombian strain of Trypanosoma cruzi with different degrees of virulence: influence on pathological features during chronic infection in mice
Re-infections with Trypanosoma cruzi are an aggravating factor for Chagas disease morbidity. The Colombian strain of T. cruzirepresents multiclonal populations formed by clonally propagating organisms with different tropisms and degrees of virulence. In the present study, the influence of successive inoculations with clones of the Colombian strain, exhibitin
Mem. Inst. Oswaldo Cruz. Publicado em: 28/04/2015
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6. The effect of arginine dietary supplementation in broiler breeder hens on offspring humoral and cell-mediated immune responses
The influence of supplementing the diet of broiler breeder hens with arginine (Arg) on their offspring's humoral and cell-mediated immune response was evaluated in two experiments. In experiments I and II, breeder hens were fed diets containing graded levels of Arg (0.943, 1.093, 1.243, 1.393 and 1.543% digestible Arg). In experiment I, the offspring was ran
Rev. Bras. Cienc. Avic.. Publicado em: 2014-06
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7. Efeito da resistência de Spodoptera frugiperda (J.E.Smith, 1797) (Lepidoptera: Noctuidae) a lambda-cyhalothrin na interação com o milho geneticamente modificado (MON810) e na resposta imunológica ao parasitismo por Campoletis af / Effect of resistance of Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae) to lambda-cyhalothrin on the interaction with genetically modified maize (MON810) and the immune response to parasitization by Campoletis aff. flavicincta (Hymenoptera: Ichneumonidae)
Fitness costs of insect resistance to insecticides can be exploited by integrating other pest control strategies in Integrated Pest Management (IPM) programs. The objective of this research was to evaluate the existence of fitness costs associated with the resistance of Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) to the pyrethroid insecticid
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/05/2012
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8. Direcionando as proteínas MSP-119 de Plasmodium vivax e Plasmodium yoelii para células dendríticas in vivo: análise das respostas imunes celular humoral. / Targeting Plasmodium vivax and Plasmodium yoelii MSP-119 proteins to dendritic cells in vivo: analysis of cellular and humoral immune responses.
Células dendríticas (DCs) são células do sistema imunológico muito importantes no processo de indução de imunidade, capazes de conectar respostas imunes inata e adquirida e levar à ativação de células T e B. Recentemente demonstrou-se que é possível direcionar antígenos diretamente para as DCs in vivo através da administração de baixas doses
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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9. Resposta imune de suínos imunizados pela via nasal com proteínas de roptrias do Toxoplasma gondii
Toxoplasma gondii is an obligate intracellular parasite that infects a wide range of hosts including human beings. Herbivores are the main domestic infection sources for humans, and pork is considered the most important route of transmission. Recent decades have witnessed a great increasing in the number of technologies and immunological research to produce
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/03/2011
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10. An experimental protocol for the establishment of dogs with long-term cellular immune reactions to Leishmania antigens
Domestic dogs are considered to be the main reservoirs of zoonotic visceral leishmaniasis. In this work, we evaluated a protocol to induce Leishmania infantum/Leishmania chagasi-specific cellular and humoral immune responses in dogs, which consisted of two injections of Leishmania promastigote lysate followed by a subcutaneous inoculation of viable promastig
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-03
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11. Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines
Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to c
Publicado em: 2011
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12. Obtenção e caracterização de frações purificadas de saponinas de chenopodium quinoa e avaliação da formação de complexos do tipo iscom : atividades biológicas das frações e dos complexos formados
Chenopodium quinoa (quinoa) seeds are a rich protein source and well-known for their high saponin content. Chemically, quinoa saponins are triterpene glycosides being phytolaccagenic, hederagenin, oleanolic and serjanic acids the most common aglycones found in seeds. Its immunoadjuvant properties have been examined and the results obtained were conflicting.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011