Reserpine
Mostrando 1-12 de 164 artigos, teses e dissertações.
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1. Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials
Objective: Amantadine blocks N-methyl-D-aspartate (NMDA) receptors and has dopaminergic and noradrenergic action, a neurochemical profile that suggests its potential as an antidepressant drug. We conducted a systematic review of preclinical and clinical studies addressing the effects of amantadine in animal models of depression and in patients with depressi
Rev. Bras. Psiquiatr.. Publicado em: 11/06/2018
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2. A validated and densitometric HPTLC method for the simultaneous quantification of reserpine and ajmalicine in Rauvolfia serpentina and Rauvolfia tetraphylla
ABSTRACT High performance thin layer chromatographic method (HPTLC) has been developed for the quantification of reserpine and ajmalicine in root part of two different population of Rauvolfia serpentina (L.) Benth. ex Kurz and Rauvolfia tetraphylla L., Apocynaceae, collected from Punjab and Uttarakhand. HPTLC of methanolic extract of root containing indole a
Rev. bras. farmacogn.. Publicado em: 2016-10
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3. Synthesis and DPPH scavenging assay of reserpine analogues, computational studies and in silico docking studies in AChE and BChE responsible for Alzheimer's disease
A doença de Alzheimer (DA) é uma doença neurodegenerativado sistema nervoso central, em rápido crescimento, e antioxidantes ajudam a suprimir o estresse oxidativo causado por radicais livres, responsávies pela DA. Avaliou-se, biologicamente, série de derivados sintéticos de indol selecionados para identificar novos antioxidantes. A maioria dos compost
Braz. J. Pharm. Sci.. Publicado em: 2015-03
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4. Carbapenem and cefoxitin resistance of Klebsiella pneumoniae strains associated with porin OmpK36 loss and DHA-1 β-lactamase production
Clinical isolates of carbapenem-resistant Klebsiella pneumoniae (K. pneumoniae) strains are being increased worldwide. Five pan-resistant K. pneumoniae strains have been isolated from respiratory and ICU wards in a Chinese hospital, and reveal strong resistance to all β-lactams, fluoroquinolones and aminoglycosides. Totally 27 β-lactamase genes and 2 membr
Braz. J. Microbiol.. Publicado em: 2013
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5. Molecular characterization of the first fluoroquinolone resistant strains of Streptococcus agalactiae isolated in Brazil
Three isolates of Streptococcus agalactiae, recovered from residents of the metropolitan area of Rio de Janeiro with significant bacteriuria, were found to be resistant to levofloxacin. Determination of the minimal inhibitory concentration (MIC) confirmed one isolate as intermediate and two as resistant to levofloxacin. No reduction in levofloxacin MIC was o
Braz J Infect Dis. Publicado em: 2012-10
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6. A validated method using RP-HPLC for quantification of reserpine in the Brazilian tree Rauvolfia sellowii Müll. Arg. (Apocynaceae)
This study describes a simple, fast and reproducible method using RP-HPLC-UV, in a gradient system, for quantification of reserpine in Rauvolfia sellowii stem bark. The analysis were carried out on a C18 column; mobile phase was water and acetonitrile, and separations were carried out in 10 min, flow rate of 1.0 mL min-1, 25 ºC and 268 nm. The validation da
Química Nova. Publicado em: 2012
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7. Genotoxic effect of alkaloids
Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showe
Publicado em: 2010
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8. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Publicado em: 2010
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9. EFEITOS DOS NEUROLÉPTICOS ATÍPICOS ZIPRASIDONA E AMISULPRIDA EM MODELOS ANIMAIS DE DISCINESIA TARDIA.
Tardive dyskinesia - the main side effect of long-term treatment with typical neuroleptics - has been related to nigrostriatal dopaminergic supersensitivity. Treatment with atypical neuroleptics is associated with a decreased risk for development of tardive dyskinesia. The aim of the present study was to verify the effects of several doses the atypical neuro
Publicado em: 2009
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10. INGESTÃO DA TINTURA DE VALERIANA OFFICINALIS PROTEGE DA DISCINESIA OROFACIAL INDUZIDA POR RESERPINA EM RATOS / INTAKE OF THE VALERIANA OFFICINALIS TINCTURE PROTECTS AGAINST OROFACIAL DYSKINESIA INDUCED BY RESERPINE IN RATS
Considerando as hipóteses do papel da neurotransmissão gabaérgica e do estresse oxidativo no desenvolvimento de movimentos orais associados a neuropatologias importantes, o presente estudo investigou a possível habilidade da tintura de V. officinalis na prevenção dos movimentos de mascar no vazio (MMV) induzidos por reserpina em ratos. Os animais foram
Publicado em: 2009
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11. Avaliação do potencial antileishmania dos compostos naturais isolados ácido úsnico, cumarin, quercetina e reserpina sobre as formas promastigotas e amastigotas de Leishmania Chagasi
As leishmanioses constituem-se por um complexo de doenças infectoparasitárias, causadas por parasitas do gênero Leishmania, e apresentam um espectro de sintomas variando de simples lesões cutâneas de cicatrização espontânea a lesões viscerais letais. A leishmaniose visceral, causada pela espécie Leishmania chagasi, no Brasil infecta cerca de duas m
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/08/2008
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12. Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta
Dopaminergic neurotransmission is involved in the regulation of sleep. In particular, the nigrostriatal pathway is an important center of sleep regulation. We hypothesized that dopaminergic neurons located in substantia nigra pars compacta (SNpc) could be activated by gentle handling, a method to obtain sleep deprivation (SD). Adult male C57/BL6J mice (N = 5
Brazilian Journal of Medical and Biological Research. Publicado em: 30/09/2008