Reliability Principle
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies
This review presents a historical overview of drug discovery and the non-clinical stages of the drug development process, from initial target identification and validation, through in silico assays and high throughput screening (HTS), identification of leader molecules and their optimization, the selection of a candidate substance for clinical development, a
Braz J Med Biol Res. Publicado em: 24/10/2016
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2. Trypan blue exclusion assay by flow cytometry
Dye exclusion tests are used to determine the number of live and dead cells. These assays are based on the principle that intact plasma membranes in live cells exclude specific dyes, whereas dead cells do not. Although widely used, the trypan blue (TB) exclusion assay has limitations. The dye can be incorporated by live cells after a short exposure time, and
Braz J Med Biol Res. Publicado em: 18/03/2014
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3. Dynamic Analysis and critical speed of rotating laminated conical shells with orthogonal stiffeners using generalized differential quadrature method
This paper presents effects of boundary conditions and axial loading on frequency characteristics of rotating laminated conical shells with meridional and circumferential stiffeners, i.e., stringers and rings, using Generalized Differential Quadrature Method (GDQM). Hamilton's principle is applied when the stiffeners are treated as discrete elements. The con
Lat. Am. j. solids struct.. Publicado em: 2013-03
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4. Inidoneidade fiscal no âmbito do ICMS
O objetivo do presente trabalho é estudar a inidoneidade fiscal no âmbito do ICMS e os efeitos de sua declaração. Após o estabelecimento das premissas básicas, foi abordada a idoneidade fiscal. E não poderia ser diferente, afinal, para que as críticas sobre a declaração de inidoneidade fiscal tivessem sentido, foi necessário entender a finalidade
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/10/2012
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5. A boa-fé na relação contratual e o princípio da confiança / Good-faith in contractual relationship and the reliability principle
O presente estudo centra-se na análise da evolução da relação contratual, com enfoque no aspecto da boa-fé e sua ligação com o princípio da confiança. Para tanto, faz-se necessária uma análise histórica acerca da concepção dos contratos, desde o individualismo decorrente dos anseios libertários da Revolução Francesa, até os dias atuais, qu
Publicado em: 2008
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6. Direito fundamental à coisa julgada civil : um estudo sobre a coisa julgada inconstitucional em confronto com o princípio da segurança jurídica e sua aplicação nas mais atuais e relevantes questões apreciadas pelo poder judiciário no âmbito de direito público brasileiro
This essay has the objective to appraise, analyze and to interpret what is unconstitutional resiudicata, and in the practical application of jurisprudence of national courts in public law. The Institution of the res iudicata is treated in the Brazilian Law by the Constitutional Text, by the Brazilian Civil Process Code, besides the Law of the Introduction to
Publicado em: 2008
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7. Metodologia para atualização de modelos numéricos de pontes com base em dados experimentais
Bridges are structures that due their immense dimension, long spans, long service life and structural complexity, need a regular inspection and condition assessment to guarantee their serviceability, safety and reliability. The modal model of the bridge based on dynamic measurement has been a tool to evaluate these structures. A system identification procedu
Publicado em: 2007
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8. COMPARAÇÃO DE DOIS TIPOS DE SOLUÇÃO NO POSICIONAMENTO COM RECEPTORES GPS / COMPARISON BETWEEN TWO TYPES OF SOLUTION IN THE POSITIONING WITH GPS RECEIVERS
The basic principle of GPS use consists in the simultaneous measure of the distances between the receiver antenna and at least four satellites of the constellation. Known the distance from the satellite to the receiver antenna and the satellites coordinates, it is possible to calculate the user antenna coordinates in the same reference system of the satellit
Publicado em: 2006
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9. Sobre o uso de ecstasy: uma pesquisa com vistas à formulação de intervenção preventiva / On the use of ecstasy: a study aimed at formulating preventive intervention
One objective of this study was methodological investigating the feasibility of conducting a Web-based survey with ecstasy users. The method developed for participants recruitment and data collection attained the propose proving feasible and fruitful, as well as showing great advantages as compared to personal data collecting. The second objective was to pro
Publicado em: 2005
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10. OBELISCO, contenido web al alcance de la mano
The basic principle for design and handling of any Website in the Internet or Intranet is centered in the attractiveness, easy to manage, up-to-date, reliability and accuracy. When they are administered by a person and the information generated in different levels of the organization surpasses their capacity, we find places outdated, inexact and not very coh
JISTEM - Journal of Information Systems and Technology Management. Publicado em: 2004
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11. The optimization principle in phylogenetic analysis tends to give incorrect topologies when the number of nucleotides or amino acids used is small
In the maximum parsimony (MP) and minimum evolution (ME) methods of phylogenetic inference, evolutionary trees are constructed by searching for the topology that shows the minimum number of mutational changes required (M) and the smallest sum of branch lengths (S), respectively, whereas in the maximum likelihood (ML) method the topology showing the highest m
The National Academy of Sciences.
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12. A new approach to determining the rates of recruitment of circulating leukocytes into tissues: Application to the measurement of leukocyte recruitment into atherosclerotic lesions
Recruitment of circulating monocytes into the artery wall is an important feature of early atherogenesis. In vitro studies have identified a number of adhesion molecules and chemokines that may control this process but very little work has been done to evaluate their relative importance in vivo, in part because there have been no methods available of suffici
The National Academy of Sciences of the USA.