Redox Imbalance
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
RESUMO Obesidade leva ao acúmulo de gordura e disfunção do tecido adiposo. Compostos ativos foram descritos no óleo-resina de copaíba, que apresenta efeitos anti-inflamatórios, antimicrobiais e antioxidantes. Contudo, não há dados sobre os efeitos do óleo-resina de copaíba sobre o tecido adiposo. Assim, testamos a hipótese de que o óleo-resina de
Acta Amazonica. Publicado em: 2022
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2. In vitro effect of globotriaosylceramide on electron transport chain complexes and redox parameters
Abstract: Fabry disease (FD) is an X-linked inherited disease and occurs due to mutations in GLA gene that encodes the α-galactosidase enzyme. Consequently, there is an accumulation of enzyme substrates, namely globotriaosylceramide (GB3). FD is a multisystemic disease, caused by storage of GB3 in vascular endothelia, with significant renal, cardiac and vas
An. Acad. Bras. Ciênc.. Publicado em: 19/06/2019
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3. Kidney Disease in Diabetes Mellitus: Cross-Linking between Hyperglycemia, Redox Imbalance and Inflammation
Resumo A hiperglicemia crônica é o ponto-chave das complicações macro e microvasculares associadas ao diabetes mellitus. O excesso de glicose é responsável por induzir desequilíbrio redox e inflamação sistêmica e intra-renal, desempenhando um papel crítico na patogênese da doença renal do diabetes, configurada atualmente como a principal causa d
Arq. Bras. Cardiol.. Publicado em: 06/06/2019
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4. Clinical Trials in Mitochondrial Disease: An Update on EPI-743 and RP103
Abstract Mitochondrial dysfunction results in the production of an abnormally high amount of reactive oxygen and nitrogen species, which results in redox imbalance and glutathione deficiency. Therapeutics such as EPI-743 (?-tocotrienol quinone) and RP103 (cysteamine bitartrate) have the theoretical potential to improve redox imbalance by increasing intracell
J. inborn errors metab. screen.. Publicado em: 16/05/2019
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5. Resistance Exercise Modulates Oxidative Stress Parameters and TNF-α Content in the Heart of Mice with Diet-Induced Obesity
Resumo Fundamento: A obesidade pode ser caracterizada por uma inflamação crônica de baixo grau e está associada à produção excessiva de espécies reativas de oxigênio, fatores que contribuem para doenças coronarianas e outras cardiomiopatias. Objetivo: Verificar os efeitos do treinamento resistido sobre os parâmetros de estresse oxidativo e par
Arq. Bras. Cardiol.. Publicado em: 25/04/2019
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6. Oxidative stress: therapeutic approaches for cervical cancer treatment
OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory
Clinics. Publicado em: 10/12/2018
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7. Factors that influence the redox state in children: An exploratory study
OBJECTIVE: The aim of the present study was to investigate the association of the redox state via malondialdehyde (MDA) as a lipid peroxidation biomarker and hydrophilic antioxidant capacity (HAC) with dietary, anthropometric, demographic, socio-economic and clinical variables as well as the serum concentrations of vitamins in children aged 20-36 months. Th
Clinics. Publicado em: 18/10/2018
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8. Treatment with Ilex paraguariensis (yerba mate) aqueous solution prevents hepatic redox imbalance, elevated triglycerides, and microsteatosis in overweight adult rats that were precociously weaned
Early weaning (EW) leads to overweight, visceral obesity, hyperleptinemia, and insulin resistance in adulthood. Treatment with Ilex paraguariensis (yerba mate) improves obesity and insulin resistance in these animals. Here, we evaluated the effects of chronic treatment with yerba mate on the redox balance and liver morphology of overweight early-weaned rats.
Braz J Med Biol Res. Publicado em: 21/05/2018
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9. Aqueous extract of Baccharis trimera improves redox status and decreases the severity of alcoholic hepatotoxicity
ABSTRACT The metabolism of ethanol occurs mainly in the liver, promoting increase of reactive oxygen species and nitrogen, leading to redox imbalance. Therefore, antioxidants can be seen as an alternative to reestablish the oxidizing/reducing equilibrium. The aim of this study was to evaluate the antioxidant and hepatoprotective effect of aqueous extract of
Rev. bras. farmacogn.. Publicado em: 2017-12
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10. Liver Damage Induced by Succinylacetone: A Shared Redox Imbalance Mechanism between Tyrosinemia and Hepatic Porphyrias
To show liver failure mediated by 5-aminolevulinic acid (ALA), a heme precursor accumulated in inborn and acquired porphyrias, rats were treated with succinylacetone methyl ester (SAME). Treated rats underwent the expected ALA accumulation in plasma, liver and urine as a result from inhibition of ALA dehydratase (ALAD) activity. The enzyme activity decreased
J. Braz. Chem. Soc.. Publicado em: 2017-07
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11. Inflammatory cytokines and plasma redox status responses in hypertensive subjects after heat exposure
Hypertension is characterized by a pro-inflammatory status, including redox imbalance and increased levels of pro-inflammatory cytokines, which may be exacerbated after heat exposure. However, the effects of heat exposure, specifically in individuals with inflammatory chronic diseases such as hypertension, are complex and not well understood. This study comp
Braz J Med Biol Res. Publicado em: 02/02/2016
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12. Mecanismos moleculares da ação tóxica pró-oxidante de 1,4-diamino-2-butanona, um análogo de putrescina, sobre células de mamíferos e Trypanosoma cruzi / The Molecular mechanisms of pro-oxidant activity of 1,4-diamino-2-butanone, a putrescine analogue, to mammalian cells and Trypanosoma cruzi
α-Aminocarbonyl componds such as 5-aminolevunilic acid (ALA) and aminoacetone (AA) have been shown to exhibit pro-oxidant properties. These compounds undergo phosphate-catalyzed enolization in physiological pH and subsequent aerobic oxidation, yielding reactive oxygen species, NH4+ ions and an α-oxoaldehyde highly cytotoxic. The α-aminoketone 1
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/06/2012