Rat Tracheal Smooth Muscle
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Pharmacological effects of the sesquiterpenic alcohol (-)-α-bisabolol in vascular and non-vascular smooth muscle preparations. / Efeitos farmacolÃgicos do Ãlcool sesquiterpÃnico (-)-α-bisabolol em preparaÃÃes isoladas de mÃsculo liso vasculares e nÃo-vasculares.
In this in vitro study the effects of the monocyclic sesquiterpene alcohol (-)-α-bisabolol on the contractile behavior of rat and mouse smooth muscle preparations were investigated. Under resting tonus, (-)-α-bisabolol relaxed duodenal smooth muscle preparations, whereas it showed biphasic effects in other smooth muscles, contracting endothelium-in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011
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2. Estudo do efeito relaxante de um novo composto doador de óxido nítrico em preparações de traquéias isoladas de ratos / Study of the relaxing effect of a new nitric oxide donor compound in preparations of isolated rat tracheae
This study evaluated the mechanisms of relaxation of two nitric oxide (NO) donors, ruthenium complex [Ru(terpy)(bdq)NO+]3+ (Terpy) and sodium nitroprusside (SNP) in isolated trachea of rats. The isolated trachea was sectioned into rings and contracted with carbachol in an organ chamber. The relaxing effect of Terpy and SNP was evaluated at increasing concent
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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3. Ação antiespasmódica do trans-cariofileno e o bloqueio de canais para Ca2+ em músculo liso traqueal de rato. / Antispasmodic action of the trans-caryophyllene and blocking Ca2 + channels in rat tracheal smooth muscle.
Trans-cariofileno é um constituinte importante em várias espécies de óleos essenciais de plantas medicinais usadas na medicina popular do Brasil, pertence à classe química dos sesquiterpenos e tem sido submetido a vários estudos. Aqui, o efeito deste constituinte foi avaliado no músculo liso da via aérea. As atividades biológicas do trans-cariofile
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/03/2010
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4. Participação Do Cálcio Citosólico Sobre A Ação Espasmolítica Do Ácido Ent-7a-Acetoxitraquiloban-18-Óico E De Seu Derivado Hidroxilado Em Íleo Isolado De Cobaia / Partipation of cytosolic calcium in spasmolytic action of ent-7a-acetoxytrachyloban-18-oic acid and its hidroxylated derivated on guinea-pig ileum
From the stem bark of Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae), popularly known as pimenteria da terra, was isolated the diterpene ent-7-α-acetoxytrachyloban-18-oic acid (trachylobane-360) from which it was made a structural modification in which the acetoxy group was substituted by hydroxy generating the ent-7a-hidroxitrachyloban-18-oic aci
Publicado em: 2010
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5. Inibição da contratilidade do músculo liso traqueal de ratos por um diterpeno caurano isolado de Croton argyrophylloides / Inhibition of tracheal smooth muscle contractility of rats by a diterpene isolated from Croton caurano argyrophylloides
Diversos diterpenos cauranos isolados de extratos de plantas têm mostrado ação antiespasmódica em diferentes músculos lisos. Nesse estudo, avaliamos os efeitos do rel-(1S, 4aS, 7S, 8aS)-7-(1-vinil)-tetradecahidro-1,4a-dimetilfenantreno-7,8a carbolactona-1-carboxílico (ATCC), um novo diterpeno caurano recentemente isolado de Croton argyrophylloides, em
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/12/2009
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6. Óleo essencial de Croton zehntneri e seus principais constituintes químicos anetol e estragol inibem parâmetros contráteis do músculo liso traqueal de rato. / Essential oil of Croton zehntneri and its main chemical constituent anethole and estragole inhibit parameters contractile rat tracheal smooth muscle.
O óleo essencial de Croton zehntneri e seus principais constituintes químicos anetol e estragol têm demonstrado atividade em vários tipos de tecidos excitáveis, incluindo músculos lisos. Devido à falta de estudos desses agentes no músculo liso das vias aéreas, os efeitos farmacológicos do óleo essencial de Croton zehntneri, anetol e estragol sobre
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/09/2009
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7. Relaxamento do músculo liso traqueal de rato pelo eugenol. / Relaxation of rat tracheal smooth muscle by eugenol.
Eugenol, a phenol monoterpenoid, is the main component of clove oil. This study aims to evaluate the relaxation of tracheal smooth muscle of rat by eugenol and the mechanisms underlying these effects. We used preparations of trachea of male Wistar rats maintained in aerated modified Tyrode to record isometric muscle contractions. Increasing and cumulative co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2009
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8. Participação dos canais de cálcio na hiperreatividade induzida por ovalbumina em traquéias isoladas de ratos / Role of the calcium channels on ovalbumin-induced rat airway hyperresponsiveness
In order to verify the interference of the antigenic challenge on traqueal contractility in vitro, male rats (250 -350 g) were ovalbumine (OVA)-sensitized and, 13 to 14 days later, they were challenged through the sensitizing antigen inhalation (OVA, 1 mg/ml, followed by 5 mg/ml). Animals were sacrificed immediately (SD0) or 24 hours (SD24) after the antigen
Publicado em: 2004
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9. Estudo farmacologico do óleo essencial do Croton nepetaefolius Baill sobre os musculos lisos traqueal e vascular e sobre as propriedades eletrofisiologicas de neuronios fasicos de ganglio celiaco / Pharmacological study of the essential oil of Croton nepetaefolius on both vascular and tracheal smooth muscle and on electrophysiological properties of celiac ganglion phasic neurones
Croton nepetaefolius is an aromatic bush found in brazilian Northeast region, called marmeleiro sabiá, and it is used in folk medicine as an antispasmodic and carminative agent. Its essential oil is comprised of 1,8-cineole, methyl-eugenol, xanthoxylin, terpineol and others constituents. Recent studies showed some pharmacological activities of the essential
Publicado em: 2002
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10. Effect of three weeks' treatment with budesonide on in vitro contractile and relaxant airway effects in the rat.
An investigation was carried out to determine whether the sensitivity of rat tracheal smooth muscle to contractile and relaxant drugs was affected by three weeks' treatment with subcutaneous budesonide before death. Budesonide treatment was associated with a lower thymus weight and a smaller gain in body weight than in control animals. There was, however, no
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11. Role of nitric oxide in experimental obliterative bronchiolitis (chronic rejection) in the rat.
The role of nitric oxide in obliterative bronchiolitis development, i.e., chronic rejection, was investigated in the heterotopic rat tracheal allograft model. An increase in the intragraft inducible nitric oxide synthase (iNOS) mRNA and mononuclear inflammatory cell iNOS immunoreactivity was demonstrated during progressive loss of respiratory epithelium and
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12. Cotton dust-mediated lung epithelial injury.
To determine if constituents of cotton plants might play a role in byssinosis by injuring pulmonary epithelium, we added extracts of cotton dust, green bract, and field-dried bract to human A549 and rat type II pneumocytes. Injury was measured as pneumocyte lysis and detachment, and inhibition of protein synthesis. Extracts of cotton dust and field-dried bra